Need for Nutritious Convenience Foods for the Elderly Population: A Review

Vyoma       Agarwal; Ila       Joshi
Abstract

Worldwide, the population of elderly persons is rising at a very fast rate. Elderly people have difficulties in performing day to day activities as the aging process deteriorates the normal functioning of their body. There is risk of inadequate nutrition because of difficulties in shopping for food, cooking a meal, chewing and putting food in mouth. Vision loss makes cooking, and even eating, more difficult. Some elderly people live alone or with their spouses. Cooking for one or two persons/s is not very stimulating. These changes have a great role to play in changing the eating habits of the elderly which may affect their nutrient intake. All these factors may cause nutritional deficiencies, malnutrition and other health problems among them. There are major opportunities to develop convenience food products in order to meet the changing needs of aging population. In order to get maximum product acceptance, it is important to combine the elements of convenience and affordability. While designing products for elderly, it is desirable to modify the food consistency to assist in swallowing, make it nutrient-dense and design it in a way that it can be easily handled and eaten. The packaging can be easy to open, information written in large fonts and contrasting colours to help in easy reading. The availability of nutritious ‘ready-meals’ can serve as an opportunity for elderly people who do not want to cook or have low interest in cooking. This can provide a variety of healthier food choices to them and help to reduce malnutrition. Access to nutritious convenience food products can facilitate a positive intervention to the aging consumers.
Keywords: Aging, cooking, consistency, nutritional deficiencies, healthy, affordability, nutrient dense, ready-meals.
Graphical Abstract

[1] 
Khanna K, Gupta S, Passi SJ, Seth R, Mahna R, Puri S. Textbook of Nutrition and DieteticsNew Delhi Elite Publishing House Pvt Ltd.  2015.
[2] 
WHO. World Population Aging 2015 Report 2015. Available at: www.un.org/en/development/desa/population/.../pdf/aging/WPA2015_Report.pdf
[3] 
Magalhaes JPD. What is aging? Definitions and concepts in gerontology 2011. Available at: 
                    http://www.senescence.info/aging_definition.html
[4] 
Sharma VB, Padhar BK, Meena HM. Review of anatomical and physiological changes in jara (aging) as per ayurveda. World J Pharmac Res  2019; 2(4): 554-60.
[5] 
Pantelić S, Popović M, Miloradović V, Kostić R, Milanović Z, Bratić M. Effects of short-term exercise training on cardiorespiratory fitness of male adults with myocardial infarction. J Phys Ther Sci  2013; 25(8): 929-35.
[http://dx.doi.org/10.1589/jpts.25.929] [PMID: 24259887] 
[6] 
Ferriolli E, Dantas RO, Oliveira RB, Braga FJ. The influence of ageing on oesophageal motility after ingestion of liquids with different viscosities. Eur J Gastroenterol Hepatol  1996; 8(8): 793-8.
[PMID: 8864677] 
[7] 
Pirlich M, Lochs H. Nutrition in the elderly. Best Pract Res Clin Gastroenterol  2001; 15(6): 869-84.
[http://dx.doi.org/10.1053/bega.2001.0246] [PMID: 11866482] 
[8] 
Ahmed T, Haboubi N. Assessment and management of nutrition in older people and its importance to health. Clin Interv Aging  2010; 5: 207-16.
[PMID: 20711440] 
[9] 
Weinstein JR, Anderson S. The aging kidney: physiological changes. Adv Chronic Kidney Dis  2010; 17(4): 302-7.
[http://dx.doi.org/10.1053/j.ackd.2010.05.002] [PMID: 20610357] 
[10] 
Goldman A, McKay B, Mojet J, Kremer S. Meeting the food needs of the aging population–implications for food science and technology. UIFoST 2014.
[11] 
Amarya S, Singh K, Sabharwal M. Changes during aging and their association with malnutrition. J Clin GeronGeria  2015; 6(3): 78-84.
[http://dx.doi.org/10.1016/j.jcgg.2015.05.003] 
[12] 
Heber D, Bray GA. Energy requirements. In: Exton-Smith AN,
Caird FI, Eds. Metabolic and Nutritional Disorders in the Elderly.
Bristol: John Wright and Sons Ltd In:  1980; pp. 1-2.
[13] 
Dumic I, Nordin T, Jecmenica M. StojkovicLalosevic M, Milosavljevic T, Milovanovic T. Gastrointestinal tract disorders in older age. Cana J Gastro Hepat  2019; 2019: 1-19.
[14] 
Schiffman SS. Taste and smell losses in normal aging and disease. JAMA  1997; 278(16): 1357-62.
[http://dx.doi.org/10.1001/jama.1997.03550160077042] [PMID: 9343468] 
[15] 
Schiffman SS. Influence of medications on taste and smell. World J Otorhinolaryngol Head Neck Surg  2018; 4(1): 84-91.
[http://dx.doi.org/10.1016/j.wjorl.2018.02.005] [PMID: 30035266] 
[16] 
Hurley BF, Roth SM. Strength training in the elderly: effects on risk factors for age-related diseases. Sports Med  2000; 30(4): 249-68.
[http://dx.doi.org/10.2165/00007256-200030040-00002] [PMID: 11048773] 
[17] 
Piasecki M, Ireland A, Stashuk D, Hamilton-Wright A, Jones DA, McPhee JS. Age-related neuromuscular changes affecting human vastus lateralis. J Physiol  2016; 594(16): 4525-36.
[http://dx.doi.org/10.1113/JP271087] [PMID: 26486316] 
[18] 
Johansson Y, Bachrach-Lindström M, Carstensen J, Ek AC. Malnutrition in a home-living older population: prevalence, incidence and risk factors. A prospective study. J Clin Nurs  2009; 18(9): 1354-64.
[http://dx.doi.org/10.1111/j.1365-2702.2008.02552.x] [PMID: 19077017] 
[19] 
Westergren A, Karlsson S, Andersson P, Ohlsson O, Hallberg IR. Eating difficulties, need for assisted eating, nutritional status and pressure ulcers in patients admitted for stroke rehabilitation. J Clin Nurs  2001; 10(2): 257-69.
[http://dx.doi.org/10.1046/j.1365-2702.2001.00479.x] [PMID: 11820347] 
[20] 
Zimmerman M, Snow B. nutrition through the life cycle: from childhood to the elderly years 2014. Available at: http://2012books. lardbucket.org/books/an-introduction-to-nutrition/s17-nutrition-through-the-life-cyc.html
[21] 
Nutritional Institute for Health and Clinical Excellence (NICE). Nutritional support in adults 2006. Available at: https://www.nice.org.uk/guidance/cg32/evidence/full-guideline-194889853
[22] 
Santanasto AJ, Goodpaster BH, Kritchevsky SB, et al. Body composition remodeling and mortality: the health aging and body composition study. J Gerontol A Biol Sci Med Sci  2017; 72(4): 513-9.
[PMID: 27567109] 
[23] 
Durnin JV, Womersley J. Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr  1974; 32(1): 77-97.
[http://dx.doi.org/10.1079/BJN19740060] [PMID: 4843734] 
[24] 
Amarya S, Singh K, Sabharwal M. Changes during aging and their association with malnutrition. J Clin Geron Ger  2015; 6(3): 78-84.
[http://dx.doi.org/10.1016/j.jcgg.2015.05.003] 
[25] 
Iliffe S, Kharicha K, Harari D, Swift C, Gillmann G, Stuck AE. Health risk appraisal in older people 2: the implications for clinicians and commissioners of social isolation risk in older people. Br J Gen Pract  2007; 57(537): 277-82.
[PMID: 17394730] 
[26] 
United Nations Population Fund (UNFPA). India aging report 2017. Available at: 
                    https://india.unfpa.org/sites/default/files/pub-pdf/India%20Aging%20Report%20-%202017%20%28Final%20Version%29.pdf https://india.unfpa.org/sites/default/files/pub-pdf/India%20Aging%20Report%20-%202017%20%28Final%20Version%29.pdf
[27] 
Courtin E, Knapp M. Social isolation, loneliness and health in old age: a scoping review. Health Soc Care Community  2017; 25(3): 799-812.
[http://dx.doi.org/10.1111/hsc.12311] [PMID: 26712585] 
[28] 
Locher JL, Ritchie CS, Roth DL, Baker PS, Bodner EV, Allman RM. Social isolation, support, and capital and nutritional risk in an older sample: ethnic and gender differences. Soc Sci Med  2005; 60(4): 747-61.
[http://dx.doi.org/10.1016/j.socscimed.2004.06.023] [PMID: 15571893] 
[29] 
Pirlich M, Schütz T, Kemps M, et al. Social risk factors for hospital malnutrition. Nutrition  2005; 21(3): 295-300.
[http://dx.doi.org/10.1016/j.nut.2004.06.023] [PMID: 15797669] 
[30] 
Jabs J, Devine CM. Time scarcity and food choices: an overview. Appetite  2006; 47(2): 196-204.
[http://dx.doi.org/10.1016/j.appet.2006.02.014] [PMID: 16698116] 
[31] 
Gardiner C, Geldenhuys G, Gott M. Interventions to reduce social isolation and loneliness among older people: an integrative review. Health Soc Care Community  2018; 26(2): 147-57.
[http://dx.doi.org/10.1111/hsc.12367] [PMID: 27413007] 
[32] 
Ramic E, Pranjic N, Batic-Mujanovic O, Karic E, Alibasic E, Alic A. The effect of loneliness on malnutrition in elderly population. Med Arh  2011; 65(2): 92-5.
[PMID: 21585182] 
[33] 
Wu ZQ, Sun L, Sun YH, Zhang XJ, Tao FB, Cui GH. Correlation between loneliness and social relationship among empty nest elderly in Anhui rural area, China. Aging Ment Health  2010; 14(1): 108-12.
[http://dx.doi.org/10.1080/13607860903228796] [PMID: 20155527] 
[34] 
Harada CN, Natelson Love MC, Triebel KL. Normal cognitive aging. Clin Geriatr Med  2013; 29(4): 737-52.
[http://dx.doi.org/10.1016/j.cger.2013.07.002] [PMID: 24094294] 
[35] 
Deary IJ, Corley J, Gow AJ, et al. Age-associated cognitive decline. Br Med Bull  2009; 92(1): 135-52.
[http://dx.doi.org/10.1093/bmb/ldp033] [PMID: 19776035] 
[36] 
Vafaei Z, Mokhtari H, Sadooghi Z, Meamar R, Chitsaz A, Moeini M. Malnutrition is associated with depression in rural elderly population. J Res Med Sci  2013; 18(Suppl. 1): S15-9.
[PMID: 23961277] 
[37] 
Mokhber N, Majdi M, Ali-Abadi M, et al. Association between malnutrition and depression in elderly people in Razavi Khorasan: a population based-study in Iran. Iran J Public Health  2011; 40(2): 67-74.
[PMID: 23113074] 
[38] 
Srilakshmi B. Dietetics New Delhi New Age International (P). Ltd. Publishers  In:  2014.
[39] 
Central Statistics Office. Statistical Year Book India 2011. Available at: 
                    http://www.mospi.gov.in/statistical-year-book-india/2011
[40] 
Chapman IM. Endocrinology of anorexia of ageing. Best Pract Res Clin Endocrinol Metab  2004; 18(3): 437-52.
[http://dx.doi.org/10.1016/j.beem.2004.02.004] [PMID: 15261848] 
[41] 
Agarwalla R, Saikia AM, Baruah R. Assessment of the nutritional status of the elderly and its correlates. J Family Community Med  2015; 22(1): 39-43.
[http://dx.doi.org/10.4103/2230-8229.149588] [PMID: 25657610] 
[42] 
Tabloski PA. Gerontological nursing  Pearson Higher Ed: United States In:  2013.
[43] 
Raynaud-Simon A, Revel-Delhom C, Hébuterne X. French Nutrition and Health Program, French Health High Authority. Clinical practice guidelines from the French Health High Authority: nutritional support strategy in protein-energy malnutrition in the elderly. Clin Nutr  2011; 30(3): 312-9.
[http://dx.doi.org/10.1016/j.clnu.2010.12.003] [PMID: 21251732] 
[44] 
Hickson M. Malnutrition and ageing. Postgrad Med J  2006; 82(963): 2-8.
[http://dx.doi.org/10.1136/pgmj.2005.037564] [PMID: 16397072] 
[45] 
Sura L, Madhavan A, Carnaby G, Crary MA. Dysphagia in the elderly: management and nutritional considerations. Clin Interv Aging  2012; 7: 287-98.
[PMID: 22956864] 
[46] 
Roy N, Stemple J, Merrill RM, Thomas L. Dysphagia in the elderly: preliminary evidence of prevalence, risk factors, and socioemotional effects. Ann Otol Rhinol Laryngol  2007; 116(11): 858-65.
[http://dx.doi.org/10.1177/000348940711601112] [PMID: 18074673] 
[47] 
Dey AB. Hand Book on Health Care of Elderly.A Manual for Trainers of Physicians in Primary and Secondary Health Care Facilities 1st ed New DelhiWHO, Ministry of Health and Family Welfare, AIIMS In:  2008.
[48] 
Kavya C, Santosh A. Geriatric health: assessment of nutritional status and functional ability of elderly living in rural area of Bangalore, Karnataka, India. Int J Comm Med Public Health  2016; 3(12): 3460-4.
[49] 
Jacobsson C, Axelsson K, Österlind PO, Norberg A. How people with stroke and healthy older people experience the eating process. J Clin Nurs  2000; 9(2): 255-64.
[http://dx.doi.org/10.1046/j.1365-2702.2000.00355.x] [PMID: 11111617] 
[50] 
Bartali B, Salvini S, Turrini A, et al. Age and disability affect dietary intake. J Nutr  2003; 133(9): 2868-73.
[http://dx.doi.org/10.1093/jn/133.9.2868] [PMID: 12949379] 
[51] 
Hall K, Whiting SJ, Comfort B. Low nutrient intake contributes to adverse clinical outcomes in hospitalized elderly patients. Nutr Rev  2000; 58(7): 214-7.
[http://dx.doi.org/10.1111/j.1753-4887.2000.tb01866.x] [PMID: 10941259] 
[52] 
Joshi K, Kumar R, Avasthi A. Morbidity profile and its relationship with disability and psychological distress among elderly people in Northern India. Int J Epidemiol  2003; 32(6): 978-87.
[http://dx.doi.org/10.1093/ije/dyg204] [PMID: 14681260] 
[53] 
Wadhwa A, Sabharwal M, Sharma S. Nutritional status of the elderly. Indian J Med Res  1997; 106: 340-8.
[PMID: 9361467] 
[54] 
Nilsson K, Gustafson L, Hultberg B. Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine. Int J Geriatr Psychiatry  2001; 16(6): 609-14.
[http://dx.doi.org/10.1002/gps.388] [PMID: 11424170] 
[55] 
Calvo MS, Whiting SJ, Barton CN. Vitamin D fortification in the United States and Canada: current status and data needs. Am J Clin Nutr  2004; 80(6)(Suppl.): 1710S-6S.
[http://dx.doi.org/10.1093/ajcn/80.6.1710S] [PMID: 15585792] 
[56] 
Krasinski SD, Russell RM, Samloff IM, et al. Fundic atrophic gastritis in an elderly population. Effect on hemoglobin and several serum nutritional indicators. J Am Geriatr Soc  1986; 34(11): 800-6.
[http://dx.doi.org/10.1111/j.1532-5415.1986.tb03985.x] [PMID: 3771980] 
[57] 
Abyad A. Prevalence of vitamin B12 deficiency among demented patients and cognitive recovery with cobalamin replacement. J Nutr Health Aging  2002; 6(4): 254-60.
[PMID: 12486445] 
[58] 
McLean RR, Jacques PF, Selhub J, et al. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med  2004; 350(20): 2042-9.
[http://dx.doi.org/10.1056/NEJMoa032739] [PMID: 15141042] 
[59] 
Rampersaud GC, Kauwell GP, Bailey LB. Folate: a key to optimizing health and reducing disease risk in the elderly. J Am Coll Nutr  2003; 22(1): 1-8.
[http://dx.doi.org/10.1080/07315724.2003.10719270] [PMID: 12569109] 
[60] 
Nyberg M, Olsson V, Pajalic Z, et al. Eating difficulties, nutrition, meal preferences and experiences among elderly: a literature overview from a Scandinavian context. J Food Res  2015; 4(1): 22-37.
[http://dx.doi.org/10.5539/jfr.v4n1p22] 
[61] 
Seidell JC, Visscher TL. Body weight and weight change and their health implications for the elderly. Eur J Clin Nutr  2000; 54(3)(Suppl. 3): S33-9.
[http://dx.doi.org/10.1038/sj.ejcn.1601023] [PMID: 11041073] 
[62] 
Traub LG, Odland DD. Convenience Foods and Home-Prepared Foods: Comparative Costs, Yield, and Quality. Department of Agriculture, Economics, Statistics, and Cooperatives Service  In:  1979.
[63] 
Kim S, Joo N. The study on development of easily chewable and swallowable foods for elderly. Nutr Res Pract  2015; 9(4): 420-4.
[http://dx.doi.org/10.4162/nrp.2015.9.4.420] [PMID: 26244082] 
[64] 
Hoffman R. Micronutrient deficiencies in the elderly - could ready meals be part of the solution? J Nutr Sci  2017; 6: e2.
[http://dx.doi.org/10.1017/jns.2016.42] [PMID: 28620477] 
[65] 
Harris JM, Shiptsova R. Consumer demand for convenience foods: demographics and expenditures. J Food Distribution Res 2007.
[66] 
Nakano S, Washizu A. Aiming for better use of convenience food: an analysis based on meal production functions at home. J Health Popul Nutr  2020; 39(1): 3.
[http://dx.doi.org/10.1186/s41043-020-0211-3] [PMID: 32046784] 
[67] 
Costa AI, Jongen WM. Designing new meals for an ageing population. Crit Rev Food Sci Nutr  2010; 50(6): 489-502.
[http://dx.doi.org/10.1080/10408390802544553] [PMID: 20544440] 
[68] 
WHO. Keep Fit for Life: Meeting the Nutritional needs of Older Persons 2002. Available at: 
                    whqlibdoc.who.int/publications/9241562102.pdf
[69] 
Houston DK, Nicklas BJ, Ding J, et al. Health ABC Study. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr  2008; 87(1): 150-5.
[http://dx.doi.org/10.1093/ajcn/87.1.150] [PMID: 18175749] 
[70] 
Arnal MA, Mosoni L, Boirie Y, et al. Protein pulse feeding improves protein retention in elderly women. Am J Clin Nutr  1999; 69(6): 1202-8.
[http://dx.doi.org/10.1093/ajcn/69.6.1202] [PMID: 10357740] 
[71] 
Gall MJ, Grimble GK, Reeve NJ, Thomas SJ. Effect of providing fortified meals and between-meal snacks on energy and protein intake of hospital patients. Clin Nutr  1998; 17(6): 259-64.
[http://dx.doi.org/10.1016/S0261-5614(98)80317-8] [PMID: 10205348] 
[72] 
Hooshmand B, Solomon A, Kåreholt I, et al. Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study. J Intern Med  2012; 271(2): 204-12.
[http://dx.doi.org/10.1111/j.1365-2796.2011.02484.x] [PMID: 22077644] 
[73] 
Stránský M. Nutrition in old age. Kontakt  2015; 17(3): e163-70.
[http://dx.doi.org/10.1016/j.kontakt.2015.08.004] 
[74] 
Manual A. Dietary guidelines for Indians. Nat Inst Nutrition  2011; 2: 89-117.
[75] 
Bauer JM, Verlaan S, Bautmans I, et al. Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc  2015; 16(9): 740-7.
[http://dx.doi.org/10.1016/j.jamda.2015.05.021] [PMID: 26170041] 
[76] 
Bonjour JP, Benoit V, Pourchaire O, Rousseau B, Souberbielle JC. Nutritional approach for inhibiting bone resorption in institutionalized elderly women with vitamin D insufficiency and high prevalence of fracture. J Nutr Health Aging  2011; 15(5): 404-9.
[http://dx.doi.org/10.1007/s12603-011-0003-y] [PMID: 21528169] 
[77] 
Recker RR, Hinders S, Davies KM, et al. Correcting calcium nutritional deficiency prevents spine fractures in elderly women. J Bone Miner Res  1996; 11(12): 1961-6.
[http://dx.doi.org/10.1002/jbmr.5650111218] [PMID: 8970899] 
[78] 
Bauer J, Biolo G, Cederholm T, et al. Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. J Am Med Dir Assoc  2013; 14(8): 542-59.
[http://dx.doi.org/10.1016/j.jamda.2013.05.021] [PMID: 23867520] 
[79] 
UCC MP, UCC MK, Snel H, Fornos XP, Holm J. Improving the quality of life of elderly people by co-ordinating research into malnutrition of the elderly 2005. Available at: 
                    https://www.univie.ac.at/nutri-senex/downloads/Product_development_report_D17%20final%2029906.pdf
[80] 
Blumberg J. Nutritional needs of seniors. J Am Coll Nutr  1997; 16(6): 517-23.
[PMID: 9430078] 
[81] 
Herrera MC, Tolentino RG, León SV, Vázquez CR, Francisca MV, Vega MD. Functional foods, old age and diabetes. Food Nutr Sci  2015; 6(16): 1507.
[http://dx.doi.org/10.4236/fns.2015.616155] 
[82] 
Lichtenstein AH, Rasmussen H, Yu WW, Epstein SR, Russell RM. Modified mypyramid for older adults. J Nutr  2008; 138(1): 5-11.
[http://dx.doi.org/10.1093/jn/138.1.5] [PMID: 18156396] 
[83] 
Kumari PV, Sangeetha N. Nutritional significance of cereals and legumes based food mix-A review. Int J Agri Life Sci  2017; 3(1): 115-22.
[84] 
Martone AM, Onder G, Vetrano DL, et al. Anorexia of aging: a modifiable risk factor for frailty. Nutrients  2013; 5(10): 4126-33.
[http://dx.doi.org/10.3390/nu5104126] [PMID: 24128975] 
[85] 
Peura-Kapanen L, Jallinoja P, Kaarakainen M. Acceptability of convenience food among older people. SAGE Open  2017; 7(1): 2158244017698730.
[http://dx.doi.org/10.1177/2158244017698730] 
[86] 
Park JY, Kim JN, Hong WS, Shin WS. Survey on present use and future demand for the convenience food in the elderly group. Korean J Community Nutr  2012; 17(1): 81-90.
[http://dx.doi.org/10.5720/kjcn.2012.17.1.81] 
[87] 
Saba A, Messina F, Turrini A, Lumbers M, Raats MM. Food in Later Life Project Team. Older people and convenience in meal preparation: a European study on understanding their perception towards vegetable soup preparation. Int J Consum Stud  2008; 32(2): 147-56.
[http://dx.doi.org/10.1111/j.1470-6431.2007.00660.x] 
[88] 
Davies DL. Review of the UK marketplace for convenience foods. Nutr Food Sci 2001.
[89] 
Bunger A, Soto D, Wittig E, Cariaga L, Hernández N. Development of food products containing lupin fiber and their effects in elderly people. Proceedings of the 9th International Lupin Conference, Klink/Muritz Germany Int Lupin Association 1999; pp. 438-9.
[90] 
Satusap P, Chavasit V, Kriengsinyos W, Judprasong K. Development of cereal and legume based food products for the elderly. Springerplus  2014; 3(1): 451.
[http://dx.doi.org/10.1186/2193-1801-3-451] [PMID: 26034667] 
[91] 
Guerra M, Pires A, Nunes A, et al. Formulating snacks to increase pulses intake by children and the elderly. In: International Congress on Engineering and Sustainability in the XXI Century Springer, Cham.   2017; pp. 182-90.
[92] 
Sieck GC. Physiology of aging 2003.
[93] 
Collins O, Bogue J. Designing health promoting foods for the aging population: a qualitative approach. Br Food J  2015; 117(12): 3003-23.
[http://dx.doi.org/10.1108/BFJ-04-2015-0158] 
Cite As
Current Nutrition & Food Science

Need for Nutritious Convenience Foods for the Elderly Population: A Review

Abstract

Graphical Abstract
