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Current Nutrition & Food Science

Author(s): Ana R.S. de Oliveira, Kyria J.C. Cruz, Jennifer B.S. Morais, Juliana S. Severo, Jéssica B. Beserra, Loanne R. dos Santos, Stéfany R. de Sousa Melo, Larissa M. Luz, Leidejaira A. de Sousa, Emídio M. de Matos Neto, Betânia de Jesus e Silva de Almendra Freitas, Nadir do Nascimento Nogueira and Dilina do Nascimento Marreiro*

DOI: 10.2174/1573401315666190730123842

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Association Between Magnesium and Oxidative Stress in Patients with Obesity

Page: [743 - 748] Pages: 6

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Abstract

Background: The role of minerals in preventing the generation of oxidative stress in obese individuals has been evaluated. Magnesium is an antioxidant nutrient and a cofactor of enzymes involved in the cell membrane stabilization, attenuating the effects of oxidative stress.

Objective: To evaluate the association between magnesium and concentrations of thiobarbituric acid reactive substances (TBARS) in patients with obesity and eutrophic women.

Methods: A cross-sectional study was conducted with 73 women, divided into two groups: case group (patients with obesity, n=27) and control group (eutrophic women, n=46). Measurements of body mass index and waist circumference were performed. Dietary magnesium intake was assessed by the three-day food record using the NutWin software. Urinary magnesium concentration was measured by atomic absorption spectrophotometry method. Plasma concentrations of thiobarbituric acid reactive substances (TBARS) were also determined.

Results: Mean values of dietary magnesium intake were 161.59 ± 60.04 and 158.73 ± 31.96 for patients with obesity and control group, respectively, with no significant difference between the groups studied (p >0.05). The value of urinary excretion of magnesium was lower than the reference values in both groups, with no significant difference between the groups studied (p >0.05). The plasma concentration of thiobarbituric acid reactive substances was significantly higher in patients with obesity compared to the control group (p <0.001). There was no correlation between levels of magnesium biomarkers and the concentration of TBARS (p >0.05).

Conclusion: Patients with obesity showed a reduced dietary magnesium intake which seems to induce hypomagnesuria as a compensatory mechanism. The marker of oxidative stress evaluated in this study was not influenced by magnesium.

Keywords: Biomarkers, magnesium, nutritional status, obesity, oxidative stress, women.

Graphical Abstract

[1]
Serra D, Mera P, Malandrino MI, Mir JF, Herrero L. Mitochondrial fatty acid oxidation in obesity. Antioxid Redox Signal 2013; 19(3): 269-84.
[http://dx.doi.org/10.1089/ars.2012.4875] [PMID: 22900819]
[2]
Oliveira ARS, Cruz KJC, Severo JS, et al. Hypomagnesemia and its relation with chronic low-grade inflammation in obesity. Rev Assoc Med Bras (1992) 2017; 63(2): 156-63.
[http://dx.doi.org/10.1590/1806-9282.63.02.156] [PMID: 28355377]
[3]
Horn RC, Gelatti GT, Mori NC, et al. Obesity, bariatric surgery and oxidative stress. Rev Assoc Med Bras (1992) 2017; 63(3): 229-35.
[http://dx.doi.org/10.1590/1806-9282.63.03.229] [PMID: 28489128]
[4]
Chielle EO, Casarin JN. Evaluation of salivary oxidative parameters in overweight and obese young adults. Arch Endocrinol Metab 2017; 61(2): 152-9.
[http://dx.doi.org/10.1590/2359-3997000000227] [PMID: 27901184]
[5]
Gobato RC, Seixas Chaves DF, Chaim EA. Micronutrient and physiologic parameters before and 6 months after RYGB. Surg Obes Relat Dis 2014; 10(5): 944-51.
[http://dx.doi.org/10.1016/j.soard.2014.05.011] [PMID: 25264334]
[6]
de Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev 2015; 95(1): 1-46.
[http://dx.doi.org/10.1152/physrev.00012.2014] [PMID: 25540137]
[7]
Morais JBS, Severo JS, Santos LRD, et al. Role of magnesium in oxidative stress in individuals with obesity. Biol Trace Elem Res 2017; 176(1): 20-6.
[http://dx.doi.org/10.1007/s12011-016-0793-1] [PMID: 27444303]
[8]
Morais JBS, Severo JS, de Oliveira ARS, et al. Magnesium status and its association with oxidative stress in obese women. Biol Trace Elem Res 2017; 175(2): 306-11.
[http://dx.doi.org/10.1007/s12011-016-0797-x] [PMID: 27406212]
[9]
Patel MDP, Kishore K, Patel DJ. Evaluation of oxidative stress and serum magnesium levels in south Indian obese males. IJSR 2014; 3: 229-30.
[http://dx.doi.org/10.15373/22778179/MARCH2014/77]
[10]
BRASIL. Ministério da Saúde Resolução nº466/12 Conselho Nacional de Pesquisa com Seres Humanos. Brasília: Diário Oficial da União 2012.
[11]
World Health Organization. Obesity: preventing and managing the global epidemic, technical report series. Geneva 2000.
[12]
World Health Organization. Waist circumference and waist-hip ratio: report of a WHO expert consultation. Geneva 2008.
[13]
Anção MS, Cuppari L, Draine AS, Singulem D. Programa de apoio à nutrição Nutwin: versão 15, São Paulo: Departamento de Informática em Saúde, SPDM, Unifesp/EPM 2002.
[14]
Institute of Medicine. Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. Washington, DC: National Academy Press 1997; p. 190.
[15]
Institute of Medicine. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. Washington, DC: National Academy Press 2005.
[16]
Fisberg RM, Marchioni DML, Slater B, Martini LA. Inquéritos alimentares: Métodos e Bases Científicas. São Paulo: Manole 2005.
[17]
Jaime PC, Latorre MRDO, Fornés NS, Zerbini CAF. Comparative study among two methods for energy adjustment for nutrient intake. Nutrire 2003; 26: 11-8.
[18]
Willett W, Stampfer MJ. Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 1986; 124(1): 17-27.
[http://dx.doi.org/10.1093/oxfordjournals.aje.a114366]
[19]
Elin RJ. Assessment of magnesium status. Clin Chem 1987; 33(11): 1965-70.
[PMID: 3315301]
[20]
Nicoll GW, Struthers AD, Fraser CG. Biological variation of urinary magnesium. Clin Chem 1991; 37(10 Pt 1): 1794-5.
[PMID: 1914186]
[21]
Ryan MF, Barbour H. Magnesium measurement in routine clinical practice. Ann Clin Biochem 1998; 35(Pt 4): 449-59.
[http://dx.doi.org/10.1177/000456329803500401] [PMID: 9681049]
[22]
Tietz NW. Clinical guide to laboratory tests. 3rd ed. Philadelphia: W.B. Saunders Company 1995.
[23]
Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95(2): 351-8.
[http://dx.doi.org/10.1016/0003-2697(79)90738-3] [PMID: 36810]
[24]
de Oliveira AR, Cruz KJ, Morais JB, et al. Magnesium status and its relationship with C-reactive protein in obese women. Biol Trace Elem Res 2015; 168(2): 296-302.
[http://dx.doi.org/10.1007/s12011-015-0358-8] [PMID: 25982004]
[25]
Associação Brasileira para o Estudo da Obesidade e da Síndrome Metabólica Diretrizes brasileiras de obesidade São Paulo: ABESO 2016.
[26]
Cruz KJ, de Oliveira AR, Pinto DP, et al. Influence of magnesium on insulin resistance in obese women. Biol Trace Elem Res 2014; 160(3): 305-10.
[http://dx.doi.org/10.1007/s12011-014-0044-2] [PMID: 24984789]
[27]
Schmatz R, Bitencourt MR, Patias LD, et al. Evaluation of the biochemical, inflammatory and oxidative profile of obese patients given clinical treatment and bariatric surgery. Clin Chim Acta 2017; 465: 72-9.
[http://dx.doi.org/10.1016/j.cca.2016.12.012] [PMID: 27986549]
[28]
Vieira-Potter VJ. Inflammation and macrophage modulation in adipose tissues. Cell Microbiol 2014; 16(10): 1484-92.
[http://dx.doi.org/10.1111/cmi.12336] [PMID: 25073615]
[29]
Zhang Y, Fischer KE, Soto V, et al. Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice. Arch Biochem Biophys 2015; 576: 39-48.
[http://dx.doi.org/10.1016/j.abb.2014.12.018] [PMID: 25558793]