Search Result "Time dependent inhibition"


Higher Throughput Human Hepatocyte Assays for the Evaluation of Time-Dependent Inhibition of CYP3A4

Journal: Drug Metabolism Letters
Volume: 5 Issue: 3 Year: 2011 Page: 183-191
Author(s): Albert P. Li, Utkarsh Doshi

Research Article

Ortho-Methylarylamines as Time-Dependent Inhibitors of Cytochrome P450 1A1 Enzyme

Journal: Drug Metabolism Letters
Volume: 10 Issue: 4 Year: 2016 Page: 270-277
Author(s): Jayalakshmi Sridhar,Jiawang Liu,Rajesh Komati,Richard Schroeder,Quan Jiang,Phan Tram,Kevin Riley,Maryam Foroozesh

An Examination of IC50 and IC50-Shift Experiments in Assessing Time-Dependent Inhibition of CYP3A4, CYP2D6 and CYP2C9 in Human Liver Microsomes

Journal: Drug Metabolism Letters
Volume: 2 Issue: 1 Year: 2008 Page: 51-59
Author(s): Loren M. Berry, Zhiyang Zhao

Impact of Time-Dependent Inactivation on the Estimation of Enzyme Kinetic Parameters for Midazolam

Journal: Drug Metabolism Letters
Volume: 3 Issue: 1 Year: 2009 Page: 45-53
Author(s): Craig Giragossian, Jennifer LaPerle, Rachel E. Kosa, Sarah Gillian

Evaluation of Different Approaches to Identifying a Higher Throughput Assay for Time-Dependent Inhibition (TDI)

Journal: Drug Metabolism Letters
Volume: 5 Issue: 2 Year: 2011 Page: 104-113
Author(s): M. Kajbaf, R. Longhi, S. Fontana

Cyclin-Dependent Kinase Inhibition by Flavoalkaloids

Journal: Mini-Reviews in Medicinal Chemistry
Volume: 12 Issue: 7 Year: 2012 Page: 632-649
Author(s): S. K. Jain,S. B. Bharate,R. A. Vishwakarma

Presynaptic Cell Dependent Modulation of Inhibition in Cortical Regions

Journal: Current Neuropharmacology
Volume: 7 Issue: 2 Year: 2009 Page: 125-131
Author(s): Afia B. Ali

In Vitro Evaluation of Reversible and Time-Dependent Inhibitory Effects of Kalanchoe crenata on CYP2C19 and CYP3A4 Activities

Journal: Drug Metabolism Letters
Volume: 9 Issue: 1 Year: 2015 Page: 48-62
Author(s): Charles Awortwe,Vamshi K. Manda,Cristina Avonto,Shabana I. Khan,Ikhlas A. Khan,Larry A. Walker,Patrick J. Bouic,Bernd Rosenkranz

Evaluation of Time-Dependent Cytochrome P450 Inhibition in a High-Throughput, Automated Assay: Introducing a Novel Area Under the Curve Shift Approach

Journal: Drug Metabolism Letters
Volume: 6 Issue: 1 Year: 2012 Page: 43-53
Author(s): Sophie Mukadam, Suzanne Tay, Daniel Tran, Leslie Wang, Erlie M. Delarosa, S. Cyrus Khojasteh, Jason S. Halladay, Jane R. Kenny

Ligustrazine Suppresses the Growth of HRPC Cells through the Inhibition of Cap- Dependent Translation Via Both the mTOR and the MEK/ERK Pathways

Journal: Anti-Cancer Agents in Medicinal Chemistry
Volume: 15 Issue: 6 Year: 2015 Page: 764-772
Author(s): Jiaoyan Han,Jiao Song,Xiangyun Li,Ming Zhu,Wei Guo,Wei Xing,Rongshen Zhao,Xiao He,Xiaoping Liu,Shali Wang,Yunyun Li,Hong Huang,Xiang Xu

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