Search Result "enzyme inactivation"


Impact of Time-Dependent Inactivation on the Estimation of Enzyme Kinetic Parameters for Midazolam

Journal: Drug Metabolism Letters
Volume: 3 Issue: 1 Year: 2009 Page: 45-53
Author(s): Craig Giragossian, Jennifer LaPerle, Rachel E. Kosa, Sarah Gillian

Assessment of Cytochrome P450 Enzyme Inhibition and Inactivation in Drug Discovery and Development

Journal: Current Topics in Medicinal Chemistry
Volume: 11 Issue: 4 Year: 2011 Page: 382-403
Author(s): David O. Nettleton, Heidi J. Einolf

High Throughput Quantitative Assessment of CYP Inactivation Using 2 Concentration Points

Journal: Drug Metabolism Letters
Volume: 3 Issue: 2 Year: 2009 Page: 78-82
Author(s): Daniel Albaugh, Thomas Farrell, Michael Langan, W. George Lai

The Structure of Ribosome Inactivating Proteins

Journal: Mini-Reviews in Medicinal Chemistry
Volume: 4 Issue: 5 Year: 2004 Page: 477-486
Author(s): Jon D. Robertus, Arthur F. Monzingo

Kinetics of Inactivation of Phytase (phy A) During Modification of Histidine Residue by IAA and DEP

Journal: Protein & Peptide Letters
Volume: 13 Issue: 6 Year: 2006 Page: 565-570
Author(s): Xiao-Yun Wang, Ming-Lv Sun, Dong-Min Zhao, Min Wang

Genetics of Ribosome-Inactivating Proteins

Journal: Mini-Reviews in Medicinal Chemistry
Volume: 4 Issue: 5 Year: 2004 Page: 487-492
Author(s): Martin R. Hartley, J. Michael Lord

Molecular Analysis and Modeling of Inactivation of Human CYP2D6 by Four Mechanism Based Inactivators

Journal: Drug Metabolism Letters
Volume: 6 Issue: 1 Year: 2012 Page: 7-14
Author(s): Mara Livezey, Leslie D. Nagy, Laura E. Diffenderfer, Evan J. Arthur, David J. Hsi, Jeffrey M. Holton, Laura Lowe Furge

Mechanism-Based Inactivation of Cytochrome P450 Enzymes: Chemical Mechanisms, Structure-Activity Relationships and Relationship to Clinical Drug-Drug Interactions and Idiosyncratic Adverse Drug Reactions

Journal: Current Drug Metabolism
Volume: 8 Issue: 5 Year: 2007 Page: 407-447
Author(s): Amit S. Kalgutkar, R. Scott Obach, Tristan S. Maurer

Research Article

Oxypeucedanin is a Mechanism-based Inactivator of CYP2B6 and CYP2D6

Journal: Current Drug Metabolism
Volume: 22 Issue: 11 Year: 2021 Page: 882-892
Author(s): Kehan Zhang,Yilin Li,Yao Fu,Tiantian Cui,Qian Wang,Xu Mao,Ying Peng,Jiang Zheng

Assessment of the Inactivation Potential of Desethylamiodarone on Human CYP1A1

Journal: Drug Metabolism Letters
Volume: 4 Issue: 1 Year: 2010 Page: 9-14
Author(s): Marwa E. Elsherbiny, Ayman O.S. El-Kadi, Dion R. Brocks

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