Combinatorial Chemistry & High Throughput Screening

Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full-length original research articles and reviews/mini-reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation, and Compound management) in advancing drug discovery research. Original research articles ...read more

  • ISSN (Print): 1386-2073
  • ISSN (Online): 1875-5402
  • Volume: 28
  • Issues: 19, 2025
1.6
3.1
Download PDF Flyer
Combinatorial Chemistry & High Throughput Screening
Explore Articles
About Journal
For Authors
For Editors
For Reviewers

Early View

Research Article
Curcumin Regulating Primordial Follicle Initiation by Restoring the Oxidative-antioxidant Balance

Authors: Wanjing Li, Jinbang Xu, Dan Shi, Jingyi Wang, Tao Liu, Juan Yang and Disi Deng*

DOI: 10.2174/0113862073368250250319001421

Published on: April 7, 2025

Research Article
The Regulatory Effects of Electroacupuncture on the Intestinal Flora of Mice with Ulcerative Colitis

Authors: Xinyu Gao, Enfan Xiao, Shaohui Geng, Haixu Jiang, Hesong Wang, Yuxin Zhao, Jiaxin Xie, Guangrui Huang* and Wenrui Jia

DOI: 10.2174/0113862073357858250219050156

Published on: April 7, 2025

Research Article
The Gut Microbiome and Metabolomics Profiles of Dust-exposed Rats

Authors: Xi Shen, Miaomiao Wang, Shasha Pei, Shuyu Xiao, Kun Xiao, Jinlong Li, Xiaoming Li, Qingan Xia, Heliang Liu and Fuhai Shen*

DOI: 10.2174/0113862073354023250314050225

Published on: April 7, 2025

Research Article
Sanggenol L Activates Caspase and Inhibits the NF-кB/JNK/ERK Signaling Pathway to Promote Apoptotic Cell Death in Colorectal Cancer Cells

Authors: Zhiyi Tang, Ye Li, Jie Shu, Annamalai Vijayalakshmi and Ran Luo*

DOI: 10.2174/0113862073369624250131053853

Published on: April 3, 2025

Research Article
Metformin Inhibits the Development of Lung Adenocarcinoma by Regulating the Expression of CCNA2 via E2F1

Authors: Luyao Wang*, Yinlong Huang*, Mei Tian, Mengling Hu, Kai Zhang, Chaoqun Lian, Xiaojing Wang and Jing Zhang

DOI: 10.2174/0113862073348968241101112455

Published on: April 3, 2025

Research Article
Paeonol Inhibits the MAPK Signaling Pathway by Targeting SIRT1 in AGE-Induced HUVECs Injury

Authors: Dingkun Liu, Hongrui Gao, Xiaochun Wu, Yulin Mo, Xiaobin Jia, Liang Feng* and Minghua Zhang

DOI: 10.2174/0113862073359192250311081427

Published on: March 27, 2025

Research Article
Exploring Mechanisms of Ephx2 in Treating Atherosclerosis Using Independent Cascade Model and Adverse Outcome Pathways

Authors: Caiyuzhen Zhang, Yuanwen Dai, Yong Chen, Bo Cao, Jinbing An* and Wei Pang

DOI: 10.2174/0113862073345542250220051427

Published on: March 27, 2025

Research Article
Astragalosides Promote MH7A Cell Apoptosis by Suppressing WTAP-mediated m6A Methylation of TRAIL-DR4

Authors: Xiaoya Cui, Linhui Zhang, Huimei Chen and Hui Jiang*

DOI: 10.2174/0113862073363967250308084008

Published on: March 25, 2025

Research Article
Solving Minimum Spanning Tree Problems Based on DNA Chemical Reaction Networks

Authors: Jing Yang*, yawen zheng, Zhixiang Yin, Xianya Geng and Zhen Tang

DOI: 10.2174/0113862073360358250128094601

Published on: March 18, 2025

Research Article
Jiawei Danggui Buxue Decoction Reduces Apoptosis and EMT of Renal Interstitial Fibrosis by Regulating JAK2/STAT3 Signaling Pathway

Authors: Xin Jiang, Yinghang Wang, Saiyue Qiu, Lu Tang, Meixiu Luo and Zhi Pan*

DOI: 10.2174/0113862073355322250226050458

Published on: March 11, 2025

Research Article
GLI3 is Inhibited by miR-143-3p and Attenuates Septic-induced Lung Injury and Inflammation by Targeting SFRP1

Authors: Minqing Ma, Haixia Han, Xiaoya Luo, Jiakai Lin and Bin Sun*

DOI: 10.2174/0113862073354161250220121414

Published on: March 10, 2025

Research Article
Synthesis, QSAR Study and Pharmacological Evaluation of Novel Triazolidine-2-thione Analogues as Antimicrobial, Anti-inflammatory and Antioxidant Agents

Authors: Abhishek Sharma, Rubina Bhutani*, Akanksha Gupta and Manni Dutta

DOI: 10.2174/1386207326666230302101657

Published on: March 11, 2025

Research Article
The Anti-PEDV Effects and Mechanisms of Forsythia Essential Oil Based on Network Pharmacology and Experimental Validation

Authors: Ruiping Liang, Jianbo Guo, Kai Li, Xuan Wang, Xiaoxiao Ge, Jinhui Wang, Jing Sun, Chongbo Zhao, Huanxian Shi, Rongxia Qiao, Hongqing Zheng and Xiaofei Zhang*

DOI: 10.2174/0113862073358217250225052414

Published on: March 10, 2025

Research Article
Computational Study for Preparation of Benzoimidazo[1,2-a]pyrimidines from Reaction of Benzaldehyde, Indanedione and 1H-benzo[d]imidazol-2- amine

Authors: Yas Zibaei, Leila Zare Fekri* and Mohammad Nikpassand

DOI: 10.2174/0113862073362160250217093210

Published on: March 3, 2025

Research Article
Dry Powder Inhaler of Sustained-Release Microspheres Containing Glycyrrhizin: Factorial Design and Optimization

Authors: Arpita Chakraborty, Riya Mahar and Nidhi Nainwal*

DOI: 10.2174/0113862073333147250127053403

Published on: February 28, 2025

No Record Found

LOADING