Letters in Drug Design & Discovery

Letters in Drug Design & Discovery publishes letters, full-length/mini-reviews, research articles, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity ...read more

  • ISSN (Print): 1570-1808
  • ISSN (Online): 1875-628X
  • Volume: 21
  • Issues: 19, 2024
1.2
1.8
Letters in Drug Design & Discovery

Volume 21, Issue 19, 2024


Mini-Review Article
PCOS-induced Cancers: A Brief Insight on the Relevance of Androgen and Obesity

Pp: 4587-4596

Author(s): Shreya Gupta, Divyanshu Rajput, Ratima Sood and Rohit Bhatia*

DOI: 10.2174/0115701808335436241226051501

Published on: 21 January, 2025

Mini-Review Article
A Current Review on Transdermal Delivery of Protein and Peptides: Possibilities and Challenges

Pp: 4597-4605

Author(s): Nishant Thakur*, Shivani Thakur, Yash Pal Singh, Sonima Prasad, Bhupinder Kaur and Chandan Sharma

DOI: 10.2174/0115701808357267250102054810

Published on: 10 January, 2025

Review Article
Phillygenin: A Versatile Multi-Targeted Anti-inflammatory, Hepatoprotactive and Anticancer Agent

Pp: 4606-4617

Author(s): Navin Kumar Tailor*

DOI: 10.2174/0115701808359518250120102541

Published on: 21 January, 2025

Review Article
Pros and Cons of Cardiovascular Herbal Therapy: Molecular Docking, ADMET, Physiological and Pharmacological Significance

Pp: 4618-4667

Author(s): Mounime Kadi*, Ali Berraouaan, Abderrahim Ziyyat, Hassane Mekhfi, Mohamed Bnouham and Abdelkhaleq Legssyer

DOI: 10.2174/0115701808323052241203113831

Published on: 13 December, 2024

Review Article
A Mechanistic Insight into the Effects of Marine Sources as Functional Foods Against Metabolic Syndrome: A Review Article

Pp: 4668-4682

Author(s): Javad Ghasemi, Shahnam Shamsabadi, Erfan Mahzoon, Yazdan Nazer, Vafa Baradaran Rahimi and Vahid Reza Askari*

DOI: 10.2174/0115701808344500250115114637

Published on: 20 January, 2025

Review Article open access plus
Penicillin G Acylase: A Multifunctional Catalyst with Broad Implications in Pharmaceutical Science and Industrial Applications

Pp: 4683-4697

Author(s): Roopa Lalitha and Shanthi Veerappapillai*

DOI: 10.2174/0115701808347794250102113721

Published on: 10 January, 2025

Research Article
Physically Crosslinked Polymeric Network for Controlled and Mucoadhesive Release of Miconazole for Topical Ocular Delivery

Pp: 4698-4708

Author(s): Umar Farooq, Akhtar Rasul, Yasir Mehmood*, Hira Shahid, Yousef A. Bin Jardan, Samir Ibenmoussa and Mohammed Bourhia*

DOI: 10.2174/0115701808301816241029103316

Published on: 13 January, 2025

Research Article
Design of VEGFR2 Inhibitors: Construction and Screening of Virtual Compound Libraries

Pp: 4709-4725

Author(s): Yixin Luo and Chunqi Hu*

DOI: 10.2174/0115701808334488241121054542

Published on: 27 January, 2025

Research Article
Predicting the Potential Mechanism of Radix Sophorae Flavescentis Treating Hepatocellular Carcinoma Based on the Strategies of Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation

Pp: 4726-4742

Author(s): Jing Hong, Jie Ding, Peng Wang, Xiao-Feng Zhai* and Bo Pan*

DOI: 10.2174/0115701808359324241221182323

Published on: 16 January, 2025

Research Article open access plus
Zhenwu Decoction Modulates PDE3A to Alleviate Inflammation in Diabetic Nephropathy

Pp: 4743-4755

Author(s): Fang Yao and Xueqing Chen*

DOI: 10.2174/0115701808339442241223062505

Published on: 10 January, 2025

Research Article
Deep Learning-driven Identification and Evaluation of Potential Therapeutic Agents for COVID-19 Co-infection Diseases Targeting METTL3

Pp: 4756-4781

Author(s): Xiaopeng Hu, Peijiang Pan, Lijuan Zhou, Jiemei Chu, Hailong Wang, Yanyan Liao, Yueqi Li, Yao Lin, Junjun Jiang, Li Ye, Shuaiyi Liang, Sanqi An* and Hao Liang*

DOI: 10.2174/0115701808337903241224065746

Published on: 26 December, 2024

Research Article
In silico Investigation of Coumarin-based Compounds Targeting Keap1-Nrf2 Pathway Involved in the Development of Alzheimer’s Disease

Pp: 4782-4791

Author(s): Sharmila Gote, Sonal Dubey*, Shachindra Nargund and Shankar Thapa

DOI: 10.2174/0115701808338518241224060020

Published on: 10 January, 2025

Research Article
Synthesis, Characterization and Evaluation of Antimicrobial and Antioxidant Activities of Novel Chalcone Scaffolds

Pp: 4792-4812

Author(s): Sathish Kumar Mittapalli*, Deepesh Parashar, Roshan S., Neethu M.V., Ajay Mahor, Pawan Kumar Gupta, Sagar Pamu and Iffath Rizwana

DOI: 10.2174/0115701808343967241224073513

Published on: 16 January, 2025

Research Article
One-step Conversion of Nitroarenes into Phosphoramidate Derivatives Using the Microwave-assisted Method: Greener Pastures COVID-19 Study

Pp: 4813-4825

Author(s): Reda A. Haggam*, Musa A. Said*, Nadia S. Al-Kaff, Ateyatallah Aljuhani, Mohamed R. Aouad, Nadjet Rezki, Tariq Z. Abolibda, Sobhi M. Gomha, Hassan A. El-Sayed and Alaa R. Sakr

DOI: 10.2174/0115701808352074241230111321

Published on: 31 December, 2024

Research Article
Efficacy of Ozonated Olive Oil as a Topical Treatment for Dermatophytosis Caused by T. mentagrophytes in Rat Model

Pp: 4826-4832

Author(s): Ali Mohaghegh, Mahdi Mansouri, Leila Etemad, Vahid Soheili, Atoosa Haghighzadeh, Saba Dadpour and Omid Rajabi*

DOI: 10.2174/0115701808337824250103053527

Published on: 22 January, 2025

Research Article
Development of Benzimidazole Anticancer Leads for EGFR Inhibition by 3D-QSAR Based Virtual Screening, Molecular Docking, Molecular Simulation and Drug Likeness Study

Pp: 4833-4844

Author(s): Ranjeeta Verma, Shweta Verma and Nahid Abbas*

DOI: 10.2174/0115701808344738241231072218

Published on: 10 January, 2025

Research Article
The Exploration of TCM Therapeutic Mechanism as Evidenced by Houpusanwu Decoction on GI Disorders Treatment using Systems Pharmacology

Pp: 4845-4869

Author(s): Shuailong Wang, Xulong Zhao and Yan Li*

DOI: 10.2174/0115701808340416241231063038

Published on: 10 January, 2025

Research Article
The Mechanism of 2-Methyl Valeric Acid Inhibiting Virulence Regulator Ser/Thr Phosphatase (Stp1) in Staphylococcus aureus

Pp: 4870-4881

Author(s): Yanan Yang*, Yawen Gao and Xuenan Li

DOI: 10.2174/0115701808349595241231062530

Published on: 08 January, 2025

Research Article open access plus
Ginsenoside Compound C Targets Prediction for Intervertebral Disc Degeneration Treatment

Pp: 4882-4893

Author(s): Yizhi Zhang, Ziyan Wei, Dongxin Wang, Shijie Chen, Fengguang Yang, Jingwen Jia, Xiaoming Qiu* and Xuewen Kang*

DOI: 10.2174/0115701808354770241231055915

Published on: 08 January, 2025

Research Article
Screening of Novel 1,2,4-triazine Clubbed 1,2,3-triazole Derivatives as Α-glucosidase Inhibitors: In Silico Study

Pp: 4894-4918

Author(s): Neha Chaturvedi, Sushanta Bhattacharya, Vivek Asati*, Samir Chtita, Savaş Kaya, Abdulrahman A. Almehizia and Raghvendra Dubey*

DOI: 10.2174/0115701808350303241230081711

Published on: 08 January, 2025