Letters in Drug Design & Discovery

Letters in Drug Design & Discovery publishes letters, full-length/mini-reviews, research articles, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity ...read more

  • ISSN (Print): 1570-1808
  • ISSN (Online): 1875-628X
  • Volume: 22
  • Issues: 16, 2025
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Letters in Drug Design & Discovery

Volume 21, Issue 17


Perspective
Enhanced Permeation Retention Effect - Modeling and Imaging Approaches for Nanoparticle-mediated Anti-cancer Diagnostics or Therapy

Pp: 3633-3638

Author(s): Suresh P.K.*

DOI: 10.2174/0115701808306902240604071741

Mini-Review Article
Isoquercetin Neuroprotective Molecular Targets in Parkinson’s Disease: Recent Highlights and Future Perspectives

Pp: 3639-3647

Author(s): Dilpreet Kaur and Shamsher Singh*

DOI: 10.2174/0115701808294683240531111346

Mini-Review Article
Pyrazolone Derivatives: Synthetic Chemistry, Exploring Pharmacological Activity - A Mini Review

Pp: 3648-3658

Author(s): Shilpi Pathak*, Sonia Singh and Neetu Agrawal

DOI: 10.2174/0115701808305582240604113524

Review Article
Herbal and Dietary Supplements for Hypertension Management

Pp: 3659-3693

Author(s): Mounia Driouech*, Mounime Kadi, Abderrahim Ziyyat, Hassane Mekhfi, Mohamed Bnouham and Abdelkhaleq Legssyer

DOI: 10.2174/0115701808297606240628065101

Review Article
The Essential Role of Herbal-based Therapies in Combatting Acne Vulgaris

Pp: 3694-3705

Author(s): Sonali Jayronia, Sudhanshu Mishra and Kanchan Kohli*

DOI: 10.2174/0115701808328901240926153014

Research Article
Identification of Pyrroloimidazoles as Potential Inhibitors of WDR5-WIN-Site by 3D-QSAR Molecular Simulation

Pp: 3706-3722

Author(s): Xiao Die Chen, Yuan Ze Shi, Na Yu, Jia Li Li, Jin Ping Wu, Xue Min Zhao, Mao Shu* and Zhi Hua Lin

DOI: 10.2174/1570180820666230829105308

Research Article
Construction of an Adenovirus Vector with Laco-regulated Antigen Expression Using the SARS-Cov-2 Spike as a Transgene Model

Pp: 3723-3729

Author(s): Anita Artarini*, Annisa Rahma Bassalamah, Arrie Arifa Arbuati, Tia Hadianti, Katherine Vanya Prasetya, Marselina Irasonia Tan, Dessy Natalia, Catur Riani and Ernawati Arifin Giri-Rachman

DOI: 10.2174/0115701808293712240516105131

Research Article
Electrochemical Modification of Metronidazole and its Application as Antibacterial and Potential Drug Agent

Pp: 3730-3740

Author(s): Samuel Attah Egu*, Sunday Okpanachi Idih, Favour Moses Idih, Ruth Foluke Aminu, Lawrence Achimugu, Aminu Omale, Jamila Audu Omale, Lian Ojotule Abah and Emmanuel Amlabu

DOI: 10.2174/0115701808281133240424055511

Research Article
Synthesis, Characterization, Antibacterial Evaluation, and Enzyme Inhibition Activity of a Novel Nitrogen-containing Heterocyclic Sulfonamide

Pp: 3741-3756

Author(s): Jingyao Kong, Xue Zhang and Guangshan Xuan*

DOI: 10.2174/0115701808308364240422131751

Research Article
Preparation and Physicochemical Properties of a Thermosensitive Hydrogel-based Lipopeptide Biosurfactant

Pp: 3757-3764

Author(s): Sepehr Afsharipour, Mohammad Amin Raeisi Estabragh, Amirhossein Namaki, Mandana Ohadi*, Mohammad Hassan Moshafi, Ibrahim M. Banat and Gholamreza Dehghannoudeh*

DOI: 10.2174/0115701808296878240419065845

Research Article
Unveiling Novel HIV-1 Protease Inhibitors through an Integrated Analysis of 3D-QSAR, Molecular Docking, and Binding Free Energy

Pp: 3765-3789

Author(s): Guozheng Zhou, Yujie Shi and Yan Li*

DOI: 10.2174/0115701808300511240527130649

Research Article open access plus
The Potential Effects and Mechanisms of Rhododendron molle against Rheumatoid Arthritis Based on Network Pharmacology and Molecular Docking

Pp: 3790-3800

Author(s): Xianxian Zhao, Yu Shen, Yongchun Huang, Xinyuan Li, Liangfang Dai and Xiangdong Luo*

DOI: 10.2174/0115701808300289240530114612

Research Article
LC-MS/MS of Dexamethasone in Rabbit Vitreous Liquid Delivered through Novel Self-nanoemulsifying Drug Delivery Systems

Pp: 3801-3811

Author(s): Yelda Komesli*, Fatma Tuba Gözet and Behiye Oztürk Şen

DOI: 10.2174/0115701808291399240528095138

Research Article
Rheum khorasanicum Decreases Migration and Induces Apoptosis in the MDA-MB-231 Breast Cancer Cell Line

Pp: 3812-3822

Author(s): Mitra Mehrabani, Zahra Miri, Kobra Bahrampour Juybari, Rezvan Najafi, Maryamossadat Mirtajaddini Goki, Najmeh Aminizadeh, Mohammad Hadi Nematollahi, Saeede Vasei, Mehrnaz Mehrabani* and Arian Amirkhosravi

DOI: 10.2174/0115701808297489240531111626

Research Article
The Hepatoprotective Effect of a Newly Synthesized 5-mercapto-1,2,4-triazole Derivative based on Nalidixic Acid against CCl4 induced Oxidative Stress in Mice

Pp: 3823-3829

Author(s): Ibrahim Mhaidat*, Lena Tahat, Ghada Alomari, Laiali AL-Quraan, Abeer Gharaibeh and Bahaa Al-Trad

DOI: 10.2174/0115701808294306240613104855

Research Article
A Combination of Catechin and Metformin: Its Preclinical Efficacy and Safety in STZ-Induced Diabetic Rats

Pp: 3830-3838

Author(s): Jyoshna Dash, Gurudutta Pattnaik, Ashirbad Nanda, Goutam Ghosh, Goutam Rath and Biswakanth Kar*

DOI: 10.2174/0115701808304505240628103332

Research Article
Molecular Dynamics Simulations and Binding Free Energy Calculations to Discover New Insights into NLRP3 Inhibitors

Pp: 3839-3850

Author(s): Karla Joane da Silva Menezes, Fernanda De França Genuíno Ramos Campos, Marianny de Souza, Daniel Calazans Medeiros, Igor José dos Santos Nascimento* and Ricardo Olimpio de Moura

DOI: 10.2174/0115701808303890240620074039

Research Article
Rings in “Lead-like Drugs”

Pp: 3851-3857

Author(s): Luca Mendes Lampert, Bruno Ruszczyk Machado, Angélica Rocha Joaquim and Fernando Fumagalli*

DOI: 10.2174/0115701808306429240703100350

Research Article
Dynamic Comparison of Binding Pocket of Berberine Protein Crystals

Pp: 3872-3885

Author(s): Jin-Rong Ma, Qiu-Rong Huang, Ruo-Jun Man, Lin-Guo Zhao* and Dong-Dong Li*

DOI: 10.2174/0115701808291656240722095841