Medicinal Chemistry

Medicinal Chemistry, a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, full-length/mini-review articles, short communications, letters, and guest-edited thematic issues covering recent research and developments in ...read more

  • ISSN (Print): 1573-4064
  • ISSN (Online): 1875-6638
  • Volume: 21
  • Issues: 10, 2025
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Medicinal Chemistry

Volume 21, Issue 4, 2025


Review Article
One-Pot Synthesis of Benzoxazoles: A Promising Approach to Aromatic Heterocyclic Compounds Preparation

Pp: 251-263

Author(s): Monika Chauhan and Sumitra Nain*

DOI: 10.2174/0115734064326002240912102121

Published on: 25 September, 2024

Review Article
Pharmacological Evaluation of Bioisosterically Replaced and Triazole- Tethered Derivatives for Anticancer Therapy

Pp: 264-293

Author(s): Dipesh Kumar, Salahuddin*, Avijit Mazumder, Rajnish Kumar, Mohamed Jawed Ahsan, Mohammad Shahar Yar, Abbussalam, Pankaj Kumar Tyagi and M.V.N.L. Chaitanya

DOI: 10.2174/0115734064320533240903062533

Published on: 19 September, 2024

Research Article
In Silico Analysis and Molecular Docking of Human Antimicrobial Peptides for Targeting Monkeypox Virus: Potential Therapeutic Implications of Histatin 5 Peptide

Pp: 294-308

Author(s): Deeksha Sarojini Devi Radhakumar, Sundar Thiyagarajan, Kaushik Rajaram and Rajesh Parsanathan*

DOI: 10.2174/0115734064312418240614104220

Published on: 20 September, 2024

Research Article
Synthesis, Characterization, and In Vitro and In Silico Studies of New Triazole Derivatives as Aromatase Inhibitors

Pp: 309-318

Author(s): Zeynep Livanur Uzmez*, Derya Osmaniye*, Yusuf Ozkay and Zafer Asım Kaplancıklı

DOI: 10.2174/0115734064316112240722092935

Published on: 18 September, 2024

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      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
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      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
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      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
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      • 11: 316251330
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      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:63
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
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      • 13. app/Models/Issue.php:157
      • 14. app/Http/Controllers/IssueController.php:861
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
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      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/IssueController.php:863
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
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      310μsbetabenthamscien_newVolume.php#88
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      • 13. app/Models/Volume.php:88
      • 14. app/Http/Controllers/IssueController.php:865
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select v.*, j.title, j.subtitle, y.year from volume v inner join journal j on v.journal_id = j.journal_id inner join year y on v.year_id = y.id where 1 and v.volume_id = 3633
      450μsbetabenthamscien_newVolume.php#292
      Backtrace
      • 11. app/Models/Volume.php:292
      • 12. app/Http/Controllers/IssueController.php:867
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 50 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`last_modified` desc
      91.12msbetabenthamscien_newArticle.php#527
      Backtrace
      • 13. app/Models/Article.php:527
      • 14. app/Http/Controllers/IssueController.php:868
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 50 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`last_modified` desc
      13.02msbetabenthamscien_newArticle.php#527
      Backtrace
      • 13. app/Models/Article.php:527
      • 14. app/Http/Controllers/IssueController.php:869
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select substring_index(GROUP_CONCAT(i.nicename ORDER BY i.priority SEPARATOR ', '), ',', 3) as indexing_title, COUNT(i.nicename) as indexing_occurrences from `indexing_journal` as `ij` inner join `indexing_agencies` as `i` on `ij`.`index_id` = `i`.`index_id` where `ij`.`journal_id` = 50 and `i`.`status` = 1 and `i`.`index_flag` = 1 group by `ij`.`journal_id` limit 1
      800μsbetabenthamscien_newIndexing.php#415
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      Backtrace
      • 14. app/Models/Indexing.php:415
      • 15. app/Http/Controllers/IssueController.php:870
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `journal` where `journal_id` = 50 limit 1
      1.69msbetabenthamscien_newArticle.php#426
      Bindings
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      • 14. app/Models/Article.php:426
      • 15. app/Http/Controllers/IssueController.php:872
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as aggregate from (select a.publish_on,a.article_id,a.elocator, a.nid,a.pmid, a.title,a.altmetric_score,a.altmetric_url,a.kudos_url, j.content_type_access_id, first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"), a.graph_abs_lg_filename,a.is_epub, a.is_epub as epub, a.graph_abs_sm_filename,a.journal_id,a.volume_id,a.issue_id, a.doi,m.month,y.year, at.type_name article_type_name,a.html_filename,a.prc_filename,a.epub_filename,v.volume_name,i.title as issue, i.type as issue_type, js.js_title, js.js_id, (select GROUP_CONCAT(CONCAT(COALESCE(first_name, ""),"", last_name)) from author aa where aa.article_id = a.article_id) as authors from `article` as `a` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal_section` as `js` on `js`.`js_id` = `a`.`js_id` left join `journal_access` as `j` on `a`.`article_id` = `j`.`content_type_id` and `j`.`content_type` = 'a' left join `issue` as `i` on `a`.`issue_id` = `i`.`issue_id` left join `month` as `m` on `i`.`month_id` = `m`.`id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_uploaded = 1 and a.issue_id = 13949 group by `a`.`article_id`) as `aggregate_table`
      2.87msbetabenthamscien_newArticle.php#468
      Backtrace
      • 16. app/Models/Article.php:468
      • 17. app/Http/Controllers/IssueController.php:872
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 19. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.publish_on,a.article_id,a.elocator, a.nid,a.pmid, a.title,a.altmetric_score,a.altmetric_url,a.kudos_url, j.content_type_access_id, first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"), a.graph_abs_lg_filename,a.is_epub, a.is_epub as epub, a.graph_abs_sm_filename,a.journal_id,a.volume_id,a.issue_id, a.doi,m.month,y.year, at.type_name article_type_name,a.html_filename,a.prc_filename,a.epub_filename,v.volume_name,i.title as issue, i.type as issue_type, js.js_title, js.js_id, (select GROUP_CONCAT(CONCAT(COALESCE(first_name, ""),"", last_name)) from author aa where aa.article_id = a.article_id) as authors from `article` as `a` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal_section` as `js` on `js`.`js_id` = `a`.`js_id` left join `journal_access` as `j` on `a`.`article_id` = `j`.`content_type_id` and `j`.`content_type` = 'a' left join `issue` as `i` on `a`.`issue_id` = `i`.`issue_id` left join `month` as `m` on `i`.`month_id` = `m`.`id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_uploaded = 1 and a.issue_id = 13949 group by `a`.`article_id` order by cast(a.article_no as SIGNED) asc, a.publish_on asc limit 20 offset 0
      1.56msbetabenthamscien_newArticle.php#468
      Backtrace
      • 14. app/Models/Article.php:468
      • 15. app/Http/Controllers/IssueController.php:872
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3633' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      590μsbetabenthamscien_newContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/IssueController.php:900
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '13949' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      520μsbetabenthamscien_newContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/IssueController.php:907
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558051 and j.to_date >= 1745558051 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3633) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558051 and j.to_date >= 1745558051 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3633) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558051 and j.to_date >= 1745558051 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3633)
      1.78msbetabenthamscien_newUserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/IssueController.php:919
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558051 and j.to_date >= 1745558051 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13949) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558051 and j.to_date >= 1745558051 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13949) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558051 and j.to_date >= 1745558051 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13949)
      900μsbetabenthamscien_newUserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/IssueController.php:932
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `journal_access` where `content_type_id` in (143342, 143158, 143228, 143135, 143398) and `content_type` = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      780μsbetabenthamscien_newContentAccess.php#616
      Bindings
      • 0: 143342
      • 1: 143158
      • 2: 143228
      • 3: 143135
      • 4: 143398
      • 5: a
      Backtrace
      • 13. app/Models/ContentAccess.php:616
      • 14. app/Http/Controllers/IssueController.php:945
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558051 and j.to_date >= 1745558051 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13949) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558051 and j.to_date >= 1745558051 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13949) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558051 and j.to_date >= 1745558051 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 13949)
      1.18msbetabenthamscien_newUserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/IssueController.php:1022
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '143342' order by au.sequence
      420μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '143158' order by au.sequence
      440μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '143228' order by au.sequence
      450μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '143135' order by au.sequence
      380μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '143398' order by au.sequence
      410μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 627 limit 1
      340μsbetabenthamscien_newMeta.php#59
      Bindings
      • 0: 627
      Backtrace
      • 14. app/Models/Meta.php:59
      • 15. app/Http/Controllers/IssueController.php:1181
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 50 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      56.96msbetabenthamscien_newIssue.php#295
      Backtrace
      • 11. app/Models/Issue.php:295
      • 12. app/Http/Controllers/IssueController.php:1188
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues from journal j join volume v on j.journal_id = v.journal_id join year y on v.year_id = y.id where j.journal_id = 50 and y.year = 2025 order by v.volume_name+0 desc limit 1
      630μsbetabenthamscien_newIssue.php#295
      Backtrace
      • 11. app/Models/Issue.php:295
      • 12. app/Http/Controllers/IssueController.php:1189
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      830μsbetabenthamscien_newArticle.php#1959
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1959
      • 14. app/Http/Controllers/IssueController.php:1197
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 50 and `b`.`banner_from_date` <= 1745558051 and `b`.`banner_to_date` >= 1745558051 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.89msbetabenthamscien_newBanner.php#189
      Bindings
      • 0: 1
      • 1: J
      • 2: 50
      • 3: 1745558051
      • 4: 1745558051
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:189
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='4a1672d772edbc0936d77f813359943c'
      360μsbetabenthamscien_newCart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._main_menu:13
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
        _token
        q1KecImVq32o63CQ0hJy2oFFxkRZdUP2qYlKqLWX
        _previous
        array:1 [ "url" => "https://beta.benthamscience.com/issue/13949/1" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        uc_cart_id
        4a1672d772edbc0936d77f813359943c
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /issue/13949/1
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:17 [ "x-https" => array:1 [ 0 => "1" ] "host" => array:1 [ 0 => "beta.benthamscience.com" ] "priority" => array:1 [ 0 => "u=0, i" ] "cookie" => array:1 [ 0 => "XSRF-TOKEN=eyJpdiI6Iko1TVdKOStOdlNLMkRwNEpBUjRkenc9PSIsInZhbHVlIjoidGJkQmRZd1A4eTFtMUVvbTZCVnFXV2R5dCsrbXA2Sk02VTFsQTZ3YUx6R2liR1ZhZTJxNFo2TWYzazI3OXY4a0tnQkVUclpiS1FBZ0FDdS8vb2c4aEZ3d1VHc2VIOUN4YVZoWHVmVGdwdFVOTlVBUEVqVEoxb1JUaDFJTExBT1MiLCJtYWMiOiI2MmY3MDIzZTg1YWI5MTNiNWU2NjFjZmQxNjdhYmM4YmM4NjZiNDk4N2M3MzRjZTIyNmMyYTdhZjEwZjIzMDlkIiwidGFnIjoiIn0%3D; eurekaselectnew_session=eyJpdiI6Imh6SkZXYkpwUFh5dWtsc1lnMDd1c0E9PSIsInZhbHVlIjoieUN6Q0xTWldzb2g4MlpjRFkxVWQzeEVVOWNpc2dEQWhSR0tDK3dlWGVvNS9VNHJmSVlzdDBRTEFMSWY4TFlOM085TEV0YW5EZ3RNUG1qYjlIakJKUlRBbGM4WVhmSGRCOWtJenBvMEFxTHlyeDJkQVBKVEhHdElDMXhTcFZuUEsiLCJtYWMiOiIwMjMyMmE1ODdjYTU1YWEwY2JhNDZmZDY1YjEyY2Y4YzM4YzgyZDRlYjA2Y2VlYzIzOGVmMzliNDcyYzYzZTBkIiwidGFnIjoiIn0%3DXSRF-TOKEN=eyJpdiI6Iko1TVdKOStOdlNLMkRwNEpBUjRkenc9PSIsInZhbHVlIjoidGJkQmRZd1A4eTFtMUVvbTZCVnFXV2R5dCsrbXA2Sk02VTFsQTZ3YUx6R2liR1ZhZTJxNFo2TWYzazI3OXY4a0tnQkVUc" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate, br, zstd" ] "sec-fetch-dest" => array:1 [ 0 => "document" ] "sec-fetch-user" => array:1 [ 0 => "?1" ] "sec-fetch-mode" => array:1 [ 0 => "navigate" ] "sec-fetch-site" => array:1 [ 0 => "none" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "sec-ch-ua-platform" => array:1 [ 0 => ""Windows"" ] "sec-ch-ua-mobile" => array:1 [ 0 => "?0" ] "sec-ch-ua" => array:1 [ 0 => ""HeadlessChrome";v="129", "Not=A?Brand";v="8", "Chromium";v="129"" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] ]
        request_cookies
        0 of 0
        array:2 [ "XSRF-TOKEN" => "q1KecImVq32o63CQ0hJy2oFFxkRZdUP2qYlKqLWX" "eurekaselectnew_session" => "Y6G8Y7owxdAeha1EKerfLOhImj3x8PGaU0If7qVt" ]
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        #12025-04-25 05:14:11GET/issue/13949/151030