Current Gene Therapy

Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in ...read more

  • ISSN (Print): 1566-5232
  • ISSN (Online): 1875-5631
  • Volume: 25
  • Issues: 5, 2025
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Current Gene Therapy
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Early View

Review Article
Synergizing CRISPR-Cas9 with Advanced Artificial Intelligence and Machine Learning for Precision Drug Delivery: Technological Nexus and Regulatory Insights

Authors: Amrita Arup Roy, Rahul Pokale, Anoushka Mukharya, Ajinkya N. Nikam, Kamal Dua, Bola Sadashiva Satish Rao, Raviraja Neelavar Seetharam and Srinivas Mutalik*

DOI: 10.2174/0115665232342293241120033251

Published on: January 6, 2025

Review Article
Molecular Insights into RNA Modifications and their Role in Shaping Immune Responses and Tumor Microenvironments

Authors: Ashiq Ali*, Tehreem Ajmal, Aisha Khatoon, Kaynaat Akbar, Urooj Irshad, Bilal Murtaza, Ziyi ji, Abdullah Ali, Qaisar Tanveer and Zhongjing Su

DOI: 10.2174/0115665232335322241205063758

Published on: January 21, 2025

Review Article
Exploring Genetic and Receptor-Based Dopaminergic Strategies for Antidepressant Drug Development

Authors: Arzoo Pannu* and Ramesh K. Goyal

DOI: 10.2174/0115665232334693250110175517

Published on: January 21, 2025

Review Article
Plasmalogens Activate AKT/mTOR Signaling to Attenuate Reactive Oxygen Species Production in Spinal Cord Injury

Authors: Mengdan Cheng, Yan Gao, Yiqing Wu, Liangliang Zhang, Bai Xu and Xiaojie Lu*

DOI: 10.2174/0115665232330349241225074627

Published on: January 20, 2025

Research Article
siRNA Knocking Down in HepG2 Cells Identifies PFKFB4 and HNF4α as Key Genes Important for Cancer Cell Survival

Authors: Amer Imraish*, Walhan Alshaer, Tuqa Abu-Thiab, Fatima Enaya, Hamzeh J. Al‐Ameer, Afnan Al-Hunaiti, Mohammad Abumurad and Malek Zihlif

DOI: 10.2174/0115665232337735250101121115

Published on: January 17, 2025

Review Article
Development of Lentiviral Packaging Cells and Scale Up of Production to Meet the Growing Demand in Cell and Gene Therapy

Authors: Yasemin van Heuvel and Jörn Stitz*

DOI: 10.2174/0115665232332412241118063211

Published on: January 13, 2025

Research Article
O-substituted Tertiary Amine-chitosans as Promising Nanocarriers for siRNA Delivery

Authors: André Miguel Martinez Júnior, Vera Aparecida de Oliveira and Marcio José Tiera*

DOI: 10.2174/0115665232335957241122164034

Published on: January 10, 2025

Review Article
Implications of EBV-Encoded and EBV-Related miRNAs in Tumors

Authors: Prankur Awasthi, Arjun Singh Kohli, Manish Dwivedi and Saba Hasan*

DOI: 10.2174/0115665232327174241211075019

Published on: January 8, 2025

Review Article
CRISPR/Cas System: A Powerful Strategy to Improve Monogenic Human Diseases as Therapeutic Delivery; Current Applications and Challenges

Authors: Fatemeh Saberi, Zeinab Yousefi-Najafabadi, Forough Shams*, Zeinab Dehghan, Sepideh Ahmadi, Tayyebeh Pilehchi, Effat Noori, Zeinab Esmaeelzadeh, Maryam Bazgiri, Rezvan Mohammadi, Farzaneh Khani, Marzieh Sameni, Parisa Moradbeigi, Gholam Ali Kardar, Mohammad Salehi, Yong Teng and Vahid Jajarmi

DOI: 10.2174/0115665232345516241119070150

Published on: January 7, 2025

Review Article
Untangling the Genetic Threads of Alzheimer's: Insights into Risk Factors and Biomarkers

Authors: Atabak Naiyeri, Amin Moqadami and Mohammad Khalaj-Kondori*

DOI: 10.2174/0115665232338503241227111640

Published on: January 7, 2025

Review Article
The Role of Immunotherapy in Lung Cancer Treatment: Current Strategies, Future Directions, and Insights into Metastasis and Immune Microenvironment

Authors: Chen Lu Li, Xin Yuan Ma and Ping Yi*

DOI: 10.2174/0115665232340926241105064739

Published on: January 6, 2025

Research Article
Identification of the Metabolic Characteristic of Organ Fibrosis Using Microbial Analysis on RNA-seq Data

Authors: Zitong Wang, Ping Wang, Guoyou He, Liang Cheng, Tianyu Li*, Yan Wang* and Hong Li*

DOI: 10.2174/0115665232257596231011110813

Published on: January 3, 2025

Review Article
Neurotrophins as Potential Gene Therapy Targets for Huntington's Disease

Authors: Sagor Kumar Roy*, Ashima Barman, Kumary Labone Sarkar, Seidu A Richard and Bijal Arvinkumar Lacmane

DOI: 10.2174/0115665232348486241025084202

Published on: January 1, 2025

Editorial
From DNA Editing to RNA Regulation: The Breakthroughs of CRISPR and Mega-CRISPR

Authors: Dinesh Kumar, Debayan Sil, Komal, Balak Das Kurmi and Manish Kumar*

DOI: 10.2174/0115665232347515241128111207

Published on: December 4, 2024

Review Article
Unraveling Glioblastoma: TME Implication and Gene Therapy Advances

Authors: Rohith Raali and Suresh P.K.*

DOI: 10.2174/0115665232351747241113050243

Published on: November 14, 2024

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