The scope includes in vitro systems, including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase ...read more
The scope includes in vitro systems, including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; bioactivation; recent developments for the identification of drug metabolites, reactive intermediate, and glutathione conjugates.
Additionally, LC/MS and other key detection methods, including ligand binding assays, sample preparation, chromatography and separation sciences, and method development and validation, are included, with applications in drug and metabolite assays, pharmacokinetic/toxicokinetic assays, biomarker assays, immunogenicity assays, diagnostic assays.
