Letters in Drug Design & Discovery

Letters in Drug Design & Discovery publishes letters, full-length/mini-reviews, research articles, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity ...read more

  • ISSN (Print): 1570-1808
  • ISSN (Online): 1875-628X
  • Volume: 22
  • Issues: 16, 2025
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Volume 21, Issue 17

Research Article
Targeting Angiotensin-converting Enzyme Inhibitor via Enalapril Reduces Postsurgical Adhesion Band Formation

Pp: 3886-3893

Author(s): Sanaz Majnoon, Fereshteh Asgharzadeh, Reihaneh Sabbaghzadeh, Seyede Elnaz Nazari, Zahra Yarmohammadi, Nikoo Saeedi, Seyed Mahdi Hassanian, Gordon Ferns, Majid Khazaei and Amir Avan*

DOI: 10.2174/0115701808293346240726110944

Research Article
Synthesis and Anti-proliferative, Tyrosine Kinases Inhibitions of New Xanthene Derivatives and their Morphological Studies

Pp: 3894-3912

Author(s): Rafat M. Mohareb* and Maken Mohamed Ahmed

DOI: 10.2174/0115701808299889240722114041

Research Article
Physicochemical, ADMET Properties, and Molecular Docking Studies of N-benzoyl-N’-naphtylthiourea Derivatives for Anti-breast Cancer Activity

Pp: 3913-3922

Author(s): Dewi Sinta Megawati, Juni Ekowati and Siswandono Siswodihardjo*

DOI: 10.2174/1570180820666230817101819

Research Article
Exploring New Potential Pkcθ Inhibitors Using Pharmacophore Modeling, Molecular Docking Analysis, and Molecular Dynamics Simulations

Pp: 3923-3933

Author(s): Yao Yao, Wen-Wei Pang, An-Zheng Hu, Hai-Yan Chen* and Zhong-Quan Qi*

DOI: 10.2174/0115701808306828240808095807

Research Article
Computational Design of a Novel Inhibitor against COVID

Pp: 3934-3945

Author(s): Balakumar Chandrasekaran*, Pandi Boomi, Mohammad F. Bayan, Sankar Muthumanickam and Mohammad H. Alyami

DOI: 10.2174/0115701808322637240722052915

Research Article
Indirubin as an AHR Ligand: A Combined Network Pharmacology and Experimental Approach to Psoriasis Therapy

Pp: 3946-3954

Author(s): Lihong Yang, Xueli Cheng, Qian Li, Guandong Liu, Yu Lin, Muchen Xu, Wen Sun* and Jing Liu*

DOI: 10.2174/0115701808316043240718070156

Research Article
The Therapeutic Potential of Ganoderma lucidum Karst and Ziziphus jujuba Mill for Postsurgical Adhesion Band Formation

Pp: 3955-3968

Author(s): Ghazaleh Khalili-Tanha, Seyedeh Elnaz Nazari, Fereshteh Asgharzadeh, Leila Mobasheri, Maryam Babaei, Hamideh Naimi, Mina Maftooh, Seyed Mahdi Hassanian, Moein Eskandari, MohammadMostafa Askarnia-Faal, Maryam Alaei, Hamid Reza Ghorbani, Mohsen Aliakbarian, Gordon Ferns, Majid Khazaei* and Amir Avan*

DOI: 10.2174/0115701808298079240818170758

Research Article
Therapeutic Potential of Colchicum luteum against Flagellin (FliC) in Salmonella typhimurium: An In silico Approach

Pp: 3969-3982

Author(s): Mohammed Naveez Valathoor and Subhashree Venugopal*

DOI: 10.2174/0115701808334616240822055800

Research Article
Structural Optimization of Quinazolin-4-one Derivatives as Novel SARS-CoV-2 Mpro Inhibitors by Molecular Simulation

Pp: 3983-3997

Author(s): Jinping Wu, Peng Li, Yucheng Mu, Ruiguang Peng, Zhongyao Zhao, Jinke Lei, Aiping Tu, Zhiting Gao, Yixiao Bai* and Gang Wu*

DOI: 10.2174/0115701808330125240812104856

Research Article
Carya Illinoinensis-mediated Green Synthesis and Antimicrobial Screening of Zirconium Oxide Nanoparticles: The Promising Antimicrobial Agent

Pp: 3998-4004

Author(s): Wajid Rehman*, Asra Rehman, Liaqat Rasheed, Rafaqat Hussain, Shahid Iqbal, Abdul Saboor, Abdullah F. AlAsmari, Fawaz Alasmari and Momin Khan*

DOI: 10.2174/0115701808317324240903094558

Research Article
Exploring the Mechanism of Influence of Wolfberry (Lycium barbarum L.) on Pulmonary Arterial Hypertension Based on Network Pharmacology and Molecular Docking

Pp: 4005-4025

Author(s): Yang Wu, Jingjing Niu, Lei Bu, Cong Li, Yuxin Liu, Jinrui Jiang, Qingbin Xu, Ping Ma* and Ru Zhou*

DOI: 10.2174/0115701808292132240909055906

Research Article
Evaluation of the Impact of Pistacia atlantica Desf. Oleo-gum Resin on Complete Freund’s Adjuvant-induced Arthritis in a Wistar Rat Model

Pp: 4026-4036

Author(s): Mobina Toofan, Pardis Mohammadi Pour, Amir Kiani, Sajad Fakhri and Mohammad Hosein Farzaei*

DOI: 10.2174/0115701808299163240912063319

Research Article
The Therapeutic Potential of Metformin for Attenuating Postsurgical Adhesion Band Formation

Pp: 4037-4045

Author(s): Zahra Yarmohammadi*, Shima Mehrabadi*, Fereshteh Asgharzadeh, Sakineh Kazemi Noureini, Seyedeh Elnaz Nazari, Sayyed Hadi Sayyed Hoseinian, Hassan Mottaghi Moghaddam Shahri, Seyed Mahdi Hassanian, Hamid Reza Ghorbani, Gordon A. Ferns, Majid Khazaei and Amir Avan*

DOI: 10.2174/0115701808301517240827092315

Research Article
Exploring the Antitumor Potential of New Indazole-indolizines Designed by Molecular Hybridization

Pp: 4046-4056

Author(s): Liliana Ciurla-Lucescu, Elena Bîcu, Dalila Belei and Alina Ghinet*

DOI: 10.2174/0115701808323543241018053705

Research Article
Design, Synthesis, Biological Evaluation, Molecular Docking, and Molecular Dynamics Simulation Studies of Fmoc-L-Lysine Carboxamides as Promising Cytotoxic Agents

Pp: 4057-4071

Author(s): Mahalakshmi C.S. Parepalli and Rajitha Galla*

DOI: 10.2174/0115701808324766240930062735

Research Article
Mechanism of Trigonella Foenum-graecum L. against Type 2 Diabetes Mellitus: Research on Network Pharmacology & Experimental Verification

Pp: 4072-4084

Author(s): Wenya Liu, Hongting Ma, Jun Luo and Yanfeng He*

DOI: 10.2174/0115701808304547240911105921

Research Article
Bcr-Abl Inhibitory Activities of Imatinib Derivatives

Pp: 4085-4094

Author(s): Bao-Long Hou*, Jiaxu Yan, Rongrong Liu, Longquan Lv, Ruirui Feng, Xiumei Yang, Guanlin Guo and Cuiling Wang

DOI: 10.2174/0115701808308483240918115915

Research Article
Exploring the Mechanism of Action of Lycium barbarum in Treating Allergic Rhinitis Using Network Pharmacology and Molecular Docking

Pp: 4095-4108

Author(s): Hui Shao, Ning Wang, Jing Kang, Kaizhi Zheng, Zheng Ma, Jing Yang, Xiaoling Yang* and Li Hou*

DOI: 10.2174/0115701808316186240913081055