Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
Neonatal brain injury encompasses hypoxic-ischemic encephalopathy (HIE), perinatal stroke, and white matter injury. The estimated incidence of HIE in developed countries is 1.5 in 1,000 live births. Hypothermia therapy improves neurodevelopmental outcomes in only 53% of treated HIE patients. Perinatal stroke occurs in 1 per 1,600 births and is a major cause of cerebral palsy and developmental impairments. Periventricular white matter injury affects 50% of premature neonates and accounts for 90% of neurologic deficits in survivors.
Stem cell therapy has emerged as a potential treatment for neonatal brain injury. This review will present the state of the art for stem cell therapy in neonatal brain injury.
Keywords:
Cerebral palsy, Hypoxic ischemic encephalopathy, Induced pluripotent stem cell, Mesenchymal stem cell, Neonatal brain injury, Neural stem cell, Periventricular leukomalacia, Stem cell therapy, Stroke, Umbilical cord blood, Umbilical cord mesenchymal stem cells.
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Authors:Bentham Science Books