Stem Cells Between Regeneration and Tumorigenesis

Author(s): Pieter J. Slootweg and Sabina Zurac

DOI: 10.2174/9781681083315116010005

Epithelial Oral Stem Cells

Pp: 37-62 (26)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

This chapter focuses on the epithelial stem cells in oral mucosa. It starts with the characterization of the normal epithelial stem cells (location, methods of identification, stemness markers). Next, it discusses the concept of cancer stem cells: origin, cancer stem cell markers, cancer stem cells niche and interference with treatment. Finally, the chapter discusses the role of oral stem cells in oral mucosa wound repair.

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