Antiprotozoal Drug Discovery: A Challenge That Remains

Author(s): A. Valeria Pozzoli and Miriam A. Martins Alho

DOI: 10.2174/9781681083292116010005

Drugs for Parasitic Diseases - Strategies to Solve a Global Problem

Pp: 41-65 (25)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

For many years, one of the driving forces for the development of drugs has been, and still is, the pharmaceutical industry, but the need for therapeutic agents regarding unprofitable diseases makes necessary a change in this situation. Parasitic diseases are a good example since the quantity and safety of many drugs currently in use are inadequate, and the development of new agents is insufficient. In the paper herein, we discuss the main methodologies used for the development and discovery of antiparasitics, the new trends and prospects, as well as the first results achieved by supranational programs and consortia created for such purposes.

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