Developmental and Stem Cell Biology in Health and Disease

Author(s): John Ku, Wadah Alhassen, Haifen Huang, Salaheldin S. Soliman, Ahmed RN Ibrahim and Ahmed HK El-Hashash

DOI: 10.2174/9781681082196116010008

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Adult Stem Cell Niches and Their Regulatory Molecular Mechanisms

Pp: 106-120 (15)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

The activation, survival, and quiescence of stem cells (SCs) are dependent on signaling within their niche or microenvironment. There are many types of SCs and SC niches that can be found in the human body. A single organ may contain more than one niche to accommodate for both slow and fast cycling SC populations. It appears that many SC niches possess similarities in both their cellular and molecular components. This chapter focuses on cellular organization, key molecular regulators, and the role of SC niches in aging and cancer.

Keywords:

Autocrine, apoptosis, blood, canonical, extrinsic factors, growth factors, hair follicle, hematopoietic, intrinsic factors, intestine, lineage, microenvironment, mesenchymal, mechanism, neuron, paracrine, quiescence, regulation, stem cell niche, stromal, transduction.

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