Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
The process of in vivo bone generation following mechanical stimulation of cells by external distraction force is defined as “distraction osteogenesis”. The events in bone formation and neovascularization in membranous craniofacial bones during the distraction osteogenesis are presented in this chapter.
When distraction force is applied, cellular differentiation in pluripotent tissue, via specific biochemical pathways, is activated with subsequential osteogenesis.
Multifactorial interrelations between osteoblasts and other bone cells occur at the bone forming boundaries. There are several cytokines and growth factors that regulate bone generation and resorption while distraction osteogenesis.
External distraction induces formation of a pool of progenitor cells that dedicated to osteoblastogenesis and local vascularisation.
Recognition of the molecular cellular pathways of membranous distraction osteogenesis is important for the further design of efficient clinical methods for therapeutic bone regeneration.
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Authors:Bentham Science Books