Malignant Pleural Mesothelioma: Present Status and Future Directions

Author(s): Tommaso Claudio Mineo and Vincenzo Ambrogi

DOI: 10.2174/9781681081946116010023

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Prognostic Factors in Malignant Pleural Mesothelioma

Pp: 257-283 (27)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Despite recent diagnostic and therapeutic advances the prognosis of malignant pleural mesothelioma remains extremely poor. We reviewed the role of some classic (i.e. age, gender, histology, staging) and novel clinical (i.e. occult residual disease, quality of life and fluorodeoxyglucose uptake at positron emission tomography) prognosticators. Many biological and genetic machineries have been lately related with the etiology and the natural history of mesothelioma. These new factors might have a significant function in predicting the prognosis of the disease and in the next future they could reveal an important role for targeted therapies.

Keywords:

Genetics, prognostic factors, staging, thoracic surgery.

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