Abstract

There are many possible causes of abnormal liver function test results, including viral hepatitis, alcohol consumption, nonalcoholic fatty liver disease, autoimmune liver diseases, hereditary diseases, hepatobiliary malignancies or infection, gallstones, and drug-induced liver injury. Moreover, the liver may be involved in systemic diseases that mainly affect other organs. Therefore, in patients without etiology of liver injury based on screening serology and diagnostic imaging analysis, abnormal liver function test results may be due to systemic disease. In most of these patients, systemic disease should be the primary focus of treatment. However, some patients with systemic disease and severe liver injury or fulminant hepatic failure require intensive treatment of the liver.