Flagellar Mechanics and Sperm Guidance

Author(s): Manabu Yoshida and Kazuo Inaba

DOI: 10.2174/9781681081281115010008

Sperm Chemotaxis in Urochordates

Pp: 183-207 (25)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Urochordates are marine animals, and spermatozoa of many urochordates show chemotactic behavior toward conspecific eggs during fertilization. Sperm chemotaxis of the ascidian Ciona intestinalis has been particularly well investigated. The sperm-activating and sperm-attracting factor (SAAF) of the phlebobranchian ascidians are secreted from the egg cells, and identified as polyhydroxylsterolsulfates. The molecular structure of SAAFs differs in different species, and the differences may cause species-specific chemotactic responses. Ascidian spermatozoa appear to sense a SAAF concentration decrease, resulting in a transient increases in intracellular Ca2+ in the flagellum and quick changes in the swimming direction of the sperm. In this chapter, we will introduce the features and molecular mechanisms of sperm chemotaxis in urochordates, and particularly those in ascidians.

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