Vaccines for Latent Viral Infections

Author(s): Risaku Fukumoto

DOI: 10.2174/9781681081328115010009

Epstein-Barr Virus Infections and Vaccine Advances

Pp: 71-97 (27)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Epstein-Barr virus (EBV) infection is associated with a spectrum of fatal diseases including Burkitt’s lymphoma (BL) and nasopharyngeal carcinoma (NPC). Higher incidence of BL and NPC seen in developing world demands an effective vaccine to prevent infection and disease onset. EBV primarily infects people during infant or adolescent ages and establishes latent infection. Vast majority of EBVassociated diseases develop later in immune-compromised individuals, suggesting the link between host immunity and viral reactivation. This chapter discusses viral factors that EBV produces whose interactions with host may determine infection, reactivation, immune evasion and disease progression, and further reviews vaccine formulations tested to date. Knowledge in such viral factors is indispensable for vaccine advances.

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