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SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
The very rapid growth in molecular sequence data from the daily accretion of large gene and protein sequencing projects have led to issues regarding viewing and analyzing the massive amounts of data. Graphical representation and numerical characterization of DNA, RNA and protein sequences have exhibited great potential to address these concerns. We review here in brief several different formulations of these representations and examples of applications to diverse problems based on what this author had presented at the Second Mathematical Chemistry Workshop of the Americas in Bogota, Colombia in 2010. In particular, we note several insights that were gained from such representations, and the applications to the bio-medicinal field.
Keywords:
Alignment free sequence comparison, bio-medical applications, chaos generator representation, DNA graphical representation, DNA numerical characterization, DNA sequences global characteristics, DNA visualization, GRANCH applications, GRANCH techniques, identifying potential drug target regions in viruses, lattice graphs in medical applications, long range correlations, long range palindromic sequences, phylogenetic trees, protein graphical representation, protein numerical characterization, purine pyrimidine relationship, QSAR.
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Authors:Bentham Science Books