Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
There is an urgent need to explore new targets and develop novel therapeutics due to the emergence of multi-drug resistant bacteria. Recently, selected members of Carbohydrate Esterase family 4 namely peptidoglycan and exopolysaccharide de-N-acetylases from bacterial pathogens have been identified as promising antibacterial drug targets. This chapter highlights the state of the art in their physiological roles, biochemical characterization, regulation, localization, structure determination and mechanism of action. Initial efforts and strategies that will guide the development of novel inhibitors against bacterial pathogens, including biofilm forming and spore forming ones, are also reviewed.
Keywords:
Biofilm formation, enzyme inhibitors, lysozyme resistance, peptidoglycan deacetylases, polysaccharide deacetylases, spore formation, virulence factors.
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Authors:Bentham Science Books