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SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
There are experimental data showing beneficial actions of inositol and inositol hexaphosphate (InsP6) in Alzheimer’s disease and Parkinson’s disease. The different stereoisomers of inositol, myo-, epi-, scyllo- and chiro-inositol have shown efficacy in Alzheimer’s disease. The antioxidant and cation chelating properties of InsP6 are considered to be some of the mechanisms; those of myo-inositol are not clear. Insofar as psychiatric diseases, lithium salts have been in use since the 1950s for bipolar disorder. While on one hand there is reduction of myo-inositol by lithium, myo-inositol on the other hand has been found useful in psychiatric disorders, and at least in one study of bipolar disorder. Thus, further studies of myo-inositol, and InsP6 in the treatment of bipolar disorder are warranted. A clinical trial of InsP6 in bipolar disorder is underway.
Keywords:
Alzheimer’s disease, BACE 1, bipolar disorder, CGI-S, HAM-D, Levodopa, lithium, MADRS, OCD, panic disorder, Parkinson’s disease, Y-BOCS.
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Authors:Bentham Science Books