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SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
Inositol and its phosphates are integral parts of cellular signaling. InsP6 is plentiful in organisms as diverse as yeast, actinobacteria, mammals and plants. In the plant kingdom, InsP6 accumulates during seed development; at the time of germination it is broken down into lower inositol phosphates and micronutrients to maintain seedling. InsP6 is the most abundant of intracellular inositol phosphates in eukaryotes. In mammals InsP6 maintains homeostasis, stores phosphate and acts as strong antioxidant and neurotransmitter. InsP6 and other inositol phosphates including the pyrophosphates, play critical roles in cellular pathways involved in signal transduction, control of cell proliferation and differentiation, RNA export, DNA repair, energy transduction, ATP regeneration etc. By enabling communication between nucleus, cytoplasm, and the outside environment, InsP6 and the other inositol phosphates play a crucial role in many aspects of cell biology.
Keywords:
Apoptosis, ATP, auxin, cell proliferation, clathrin, coated pits, differentiation, DNA repair, eukaryote, exocytosis, FGF, MAPK, nuclear pore, PKC, prokaryote, RNA export, signal transduction, syndecan, zinc finger.
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Authors:Bentham Science Books