The Medical Lives of History`s Famous People

Author(s): William James Maloney

DOI: 10.2174/9781608059362114010009

Porphyria: The Cause of the Madness of King George

Pp: 41-46 (6)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

King George III was the reigning monarch of Great Britain who had his troops vanquished by the colonial forces during the American War for Independence. At age 50, George III began experiencing various symptoms including insomnia, stupor, restlessness, and headaches. His systems disappeared and he mysteriously recovered. Symptoms returned over a decade later and eventually led to King George III losing the royal throne. Modern research shows that the cause of King George IIIʼs illness was porphyria. Porphyrias are a group of rare diseases. This group of diseases is characterized by an enzyme deficiency in the heme biosynthesis pathway.

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