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SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
The protozoan parasite Trypanosoma cruzi, the etiologic agent of Chagas disease, is an intracellular pathogen in its vertebrate host. Here we review the process of cell invasion by T. cruzi from the perspectives of surface-surface interactions, intracellular signaling, contributions of donor membranes and the cytoskeleton, and discuss cytoplasmic entry and differentiation after escape from the parasitophorous vacuole. The chronic host-pathogen relationship depends upon immune evasion by the parasite and prevention of host apoptosis. Finally, we briefly discuss the development of cardiac autoimmunity in the pathogenesis of Chagas disease.
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Authors:Bentham Science Books