Recent Advances in Medicinal Chemistry

Author(s): V.F. Samanidou, M.K. Nika and I.N. Papadoyannis

DOI: 10.2174/9781608057962114010014

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HPLC and its Essential Role in the Analysis of Tricyclic Antidepressants in Biological Samples

Pp: 332-380 (49)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

HPLC is discussed as an essential tool for the analysis of tricyclic antidepressants in biological samples, providing clinicians with efficient fast and reliable methods to define individual optimum therapeutic concentrations in treatment of depressions. Additional information on mechanism of action, structure activity relationship and metabolism is provided. Sample preparation issues are discussed.

Keywords:

Biological fluids, HPLC, monitoring, medicinal chemistry, tricyclic antidepressants.

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