THERAPEUTIC REVOLUTION The History of Medical Oncology from Early Days to the Creation of the Subspecialty

Author(s): Pierre R. Band

DOI: 10.2174/9781608058143114010016

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Successes in Solid Tumor Chemotherapy: Three Key Examples

Pp: 146-156 (11)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

The chemotherapy of solid tumors followed the path opened by breast cancer: the use of active single agents combined for greater effectiveness in advanced disease and for their potential role in combined modality regimens. By the end of the 1960s, over 20 chemotherapeutic drugs effective against various malignancies were available to investigate these approaches. The use of combination chemotherapy in epithelial ovarian cancer, small cell lung cancer and osteogenic sarcoma showed improved response rates and duration of remission compared to previously used single drugs. Postoperative combination chemotherapy improved the survival of patients with osteogenic sarcomas.

Keywords:

Ovarian cancer, small cell lung cancer, osteogenic sarcoma.

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