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SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
The antibiotic streptomycin was the first drug used to treat TB and illustrated well the important role of nature in the fight against diseases. For example, several natural products were discovered between 1940-60´s against Mycobacterium tuberculosis being used nowadays in TB treatment as second-line drugs. Due to the importance of nature in the past and the present for TB treatment and drug discovery, a lot of attention has been given to new anti-TB drugs based on natural products nowadays, especially against MDR and XDR-TB. Considering that, the aim of the present chapter is to highlight promising natural product candidates in clinical trials against TB.
Keywords:
Tuberculosis, Mycobacterium tuberculosis, natural products, semisynthesis, drug development, treatment, multi-drug-resistant tuberculosis (MDR TB), extensive-drug-resistant tuberculosis (XDR TB), target, mechanism of action, biological evaluation, clinical studies.
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Authors:Bentham Science Books