Immunology of Pregnancy 2013

Author(s): Gérard Chaouat

DOI: 10.2174/9781608057337113010014

Part C: A Summary of Cytokine Networks and Embryo: A Short Overview

Pp: 238-279 (42)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

In this relatively short review, after recaling the immunotrophism theory and the Th1 /Th2 paradigm, and the fact that a major discovery in the field was that “immunologic” molecules are produced by cells of the reproductive tract of non-immune lineage, we try to summarize the main cytokines involvement in pregnancy, though redundancy and chaos like functions makes it sometimes impossible to ascribe a defined role to a single cytokine or even cytokine family.

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