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Thyroid nodules can be identified in approximately 5% of the population. The American Thyroid Association guidelines indicate fine needle aspiration as the most accurate method for the evaluation of a thyroid nodule; however in up to 20% of cases, cytology produces indeterminate or suspicious results that require surgery to complete the diagnosis. This chapter reviews molecular markers, which can be detected using protein-based assays, to improve the sensitivity of FNA.
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