Dynamics of Biological Macromolecules by Neutron Scattering

Author(s): Salvatore Magazu, Federica Migliardo, Antonio Benedetto, Miguel A. Gonzalez and '>Claudia Mondelli

DOI: 10.2174/978160805219611101010022

Elastic Incoherent Neutron Scattering: Biomolecular Motion Characterization by Self-Distribution-Function Procedure

Pp: 22-34 (13)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

We first focus on the role of the instrumental resolution in Elastic Incoherent Neutron Scattering (EINS) where the connection between the Self Distribution Function (SDF) and the measured EINS intensity profile is highlighted. Second we show how the SDF procedure allows both the total and the partial Mean Square Displacement (MSD) evaluation, through the total and the partial SDFs. Finally, we compare the SDF and the Gaussian procedures, by applying the two approaches to EINS data collected, by the IN13 backscattering spectrometer (ILL, Grenoble), on aqueous mixtures of two homologous disaccharides, i.e. sucrose and trehalose, and on myoglobin.

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