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SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
Encapsulation of heterologous cells allows the production of therapeutic substances selectively in the required tissues of the patient. Thus high local concentrations help to minimise side effects in other parts of the body. Nevertheless, most substances show small therapeutic windows also at their site of action. Furthermore, the timing of the release has to be adjusted to the requirements of the patient and the treatment. Regulation from the outside is therefore necessary to adjust the expression in the transplanted cells.
Keywords:
Inducible systems, gene expression, alternating magnetic field, heat shock response, regulated gene expression, heat shock promoter, encapsulation, cell therapy, biological, personalized medicine, temperature increase.
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Authors:Bentham Science Books