Abstract
SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
The development of formulations with modified release of the drug substances targeting different segments of the gastrointestinal tract is an ongoing challenge for the scientist in the field of drugs. Current manufacturing technologies are mainly focused on delayed release so that the release does not start before the formulation reaches the colon. Other technologies are based on time-delayed active substance release with a predetermined lag time, on time-delayed controlled release systems with enzymes, and on pressure controlled release systems. The release of medicinal substances incorporated into colonic-release microparticulate systems is dependent on pH, on the system's gastrointestinal transit time or on the microbial and enzymatic load of the colon. Colonic release micro/nanoparticulate systems based on natural polymers led to significant results. Recent research has shown that the most effective colon-specific micro/nanoparticulate systems are those combining several drug release principles.
Keywords:
Colon targeted drug delivery, modified release, bioavailability, inflammatory bowel disease, oral dosage forms, ulcerative colitis, polymeric prodrugs, polysaccharides, micro/nanoparticulate systems.
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Authors:Bentham Science Books