Medicinal Chemistry - Fusion of Traditional and Western Medicine

Author(s): Robert E. Smith

DOI: 10.2174/9781608051496113010020

Biology of Inflammation

Pp: 414-425 (12)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Inflammation can be a cause or a symptom of many diseases. When controlled, it is also an important part of maintaining good health. Reactive oxygen substances (ROS) are produced as part of normal, healthy aerobic metabolism, such as electron transport in the mitochondria of cells. Many foods, spices, herbs and dietary supplements contain antioxidants that can destroy ROS and prevent diseases, including arthritis, cancer, heart disease, stroke and brain diseases. Some important dietary antioxidants include vitamins A and E, oleic acid, polyunsaturated fats, omega-3 fats, resveratrol and polyphenols. Inflammation is a significant factor in many diseases, including arthritis, cancer, diabetes, heart disease, stroke, Alzheimer’s disease, hormonal diseases, osteoporosis, inflammatory bowel disease, pelvic inflammatory disease, and many others. Smoldering inflammation is a relatively low level of inflammation that occurs in diseases such as obesity, type-2 diabetes, asthma, and atherosclerosis. In many cases, these diseases of inflammation can be prevented by avoiding obesity, trans fats and saturated fats that are in the typical fast food diet consume by many people in the USA. Instead, unsaturated fats are much better. Omega- 3 fats can be taken as dietary supplements such as fish oil and flaxseed oil. They are also present in fatty fish, such as salmon. Omega-3 fats are also very important in the brain, where they play an important role in cognitive function and behavior. Inflammation plays an important role in all stages of atherosclerosis and cardiovascular disease. Inflammation is also an important factor in stroke.

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