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SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
Synthetic amino acids have particular appeal to extend our understanding of protein structure and stabilization into the realm of folded, non biological polymers. Chemists are now beginning to design biomimetic amino acids that can form both secondary and tertiary structures. An overview of the synthesis of non-protein amino acids recently used in the design of conformationally well-defined foldamers—artificial oligomers that also adopt well-defined folded conformations— are discussed.
Keywords:
Nonproteinogenic amino acids, amino acids analogues, synthesis, foldamers, single helix, double helical structure, helicate, strand, extended helix, quadruple helix, α-amino acid, glyco α-amino acids, β-amino acids, β-Substituted β- amino acids, α-substituted β-amino acids, heterocyclic β-amino acid, γ- Aminobutyric acid, pyrrole amino acid, δ-amino acids, arginine analogues, Dioxabicyclo amino acids, fullerene substituted amino acid, ferrocene substituted amino acids.
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Authors:Bentham Science Books