Mucins – Potential Regulators of Cell Functions Volume Title: Gel-Forming and Soluble Mucins

Author(s): Joseph Z. Zaretsky and Daniel H. Wreschner

DOI: 10.2174/9781608054541113010015

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Secreted Mucins: Covert Functions

Pp: 547-568 (22)

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  • * (Excluding Mailing and Handling)

Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Functions that potentially can be performed by secreted mucins have been analyzed by bioinformatics using the Motifscan and Eukaryotic Linear Motif (ELM) tools and STRING 9.0 interaction network. A number of potentially important motifs were discovered and possible functional partners of the secreted mucin glycoproteins were predicted. A new role of galactin-3 in physiological transformation of the intestinal mucus gel layers is proposed.

Keywords:

Secreted mucins, galectin-3, bioinformatics.

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