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This chapter reviews the recent findings on the synthetic methods developed for the direct introduction of a trifluoromethyl group in carbonyl compounds. It was organized by type of reagent highly considering the description of the trifluoromethylating agents, their activation mode, their asymmetric approaches, as well as applications in organic synthesis.
Keywords:
DAST, fluorine chemistry, trifluoromethyl halides, sulfur tetrafluoride, deoxo-fluor, bromine trifluoride, organoboron reagent, diethyl trifluoromethylphosphonate, trifluoromethyl bromide, fluoroform, hemiaminals of fluoral, sodium trifluoroacetate, sodium trifluoromethylacetophenone-N, Ndimethyltrimethylsilylamine adduct.