Miscellanea: Antihistamines, Dapsone, Antimalarials

Pp: 403-433 (31)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

In this chapter, three different drugs are resumed. Antihistamines are widely used in dermatological conditions to ameliorate pruritus and to inhibit the histamine release. Dapsone has been used for almost 50 years in the treatment of several infectious diseases including, leprosy and malaria and recently in the treatment of pneumocystic carinii pneumonia in patients with AIDS. Dapsone also has anti-inflammatory properties and has been used in dermatology and rheumatology. The development of the synthetic antimalarials and their use in the treatment of cutaneous diseases have been well described. Chloroquine is a 4-aminoquinoline antimalarial used in the treatment and prophylaxis of malaria. It has also been used in the treatment of hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.

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