On-Chip Pretreatment of Whole Blood by Using MEMS Technology

Author(s): Xing Chen, Dafu Cui and Jian Chen

DOI: 10.2174/978160805147211201010064

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Microfluidic Devices Targeting Blood Cell Lysis

Pp: 64-83 (20)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Cell lysis is an essential step in whole blood sample preparation, which can pave road for intracellular proteomic analysis or genomic analysis and therefore cell membrane rupture is requested for protein and gene release. In this chapter, we firstly introduce reported microfluidic devices for cell lysis. And then an example using the chemical cell lysis method in microfluidic chip is put forward in which a sandwich microfluidic chip was designed, fabricated and tested to disrupt blood cell membranes.

Keywords:

Cell lysis, MEMS, microfluidics.

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