Chemoinformatics: Directions Toward Combating Neglected Diseases

Author(s): Matheus P. Freitas, Teodorico C. Ramalho, Elaine F. F. da Cunha and Rodrigo A. Cormanich

DOI: 10.2174/978160805183011201010154

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Multivariate Image Analysis Applied to QSAR as a Tool for Mosquitoes Control: Dengue and Yellow Fever

Pp: 154-161 (8)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

An image-based QSAR approach, called Multivariate Image Analysis Applied to Quantitative Structure-Activity Relationships (MIA-QSAR) is described as a tool to model the toxicities of a series of organotin compounds against Aedes aegypti and Anopheles stephensi mosquito larvae, vectors of dengue and yellow fever. This methodology may help researchers to discover novel, potent mosquito controllers.

Keywords:

QSAR-2D, MIA-QSAR, dengue and yellow fever.

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