Functional Molecular Imaging In Hepatology

Author(s): Lasse K. Bak, Arne Schousboe and Helle S. Waagepetersen

DOI: 10.2174/978160805290511201010129

Brain Energy and Ammonia Metabolism

Pp: 129-144 (16)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Brain metabolism is in principle similar to the biochemical processes which take place in all cells and organs. However, specialization of the different cell types in the brain, i.e. neurons or glial cells, adds a complexity which differs from other organs. In this chapter, a detailed outline of the metabolic processes providing the basis for brain energy and ammonia metabolism is provided. It also contains information regarding the effects on energy metabolism of a dysfunctional ammonia homeostasis such as that related to hepatic encephalopathy (HE). Moreover, methodological tools by which these metabolic processes may be studied experimentally such as PET as well as tissue and cell preparations are reviewed.

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