Abstract

Rab9 functions in the retrieval of mannose 6-phosphate receptors (MPRs) from late endosomes and their subsequent delivery to the trans Golgi network (TGN). In this chapter, we will discuss how Rab9 is recruited onto membranes, how Rab9 functions to select and segregate MPRs into a specific microdomain depleted of Rab7, and ultimately, how Rab9-containing transport vesicles dock and fuse at the TGN.