Rab GTPases and Membrane Trafficking

Author(s): Mirjana Nordmann, Christian Ungermann and Margarita Cabrera

DOI: 10.2174/978160805365011201010132

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Role of Rab7/Ypt7 in Organizing Membrane Trafficking at the Late Endosome

Pp: 132-143 (12)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

Late endosomal biogenesis depends on the Rab7 GTPase and its interaction with effectors. Within this review, we will focus on the Rab7 activation and inactivation cycle, and identify the critical regulators and interaction partners. We will highlight the role of Rab7 in membrane tethering between late endosome and lysosome, and its function in nutrient sensing, which is coupled to the establishment of membrane contact zones and late endosomal distribution within the cell.

Keywords:

Mon1, Ccz1, Rab7, Ypt7, HOPS.

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