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SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.
Abstract
Ypt/Rab GTPases form the broadest group of GTPases in eukaryotic cells. These conserved GTPases are key regulators of intracellular trafficking. Like other monomeric GTPases, Ypt/Rabs switch between GDP- and GTP-bound forms with the help of their upstream regulators. When in the GTP-bound form, they interact with downstream effectors that mediate all vesicular transport steps, from vesicle formation to fusion. In addition, Ypt/Rabs are considered as candidates to coordinate intermediate/individual steps during vesicular transport. Due to their central role in intracellular traffic regulation, Ypt/Rabs have been implicated in human diseases ranging from diabetes and cancer to neurological and immunological disorders.
Keywords:
Ypt, Rab, GTPase, GTP-binding Protein, Membrane Trafficking, Vesicular Transport
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Authors:Bentham Science Books