Current Technologies To Increase The Transdermal Delivery Of Drugs

Author(s): Roberto Diaz-Torres

DOI: 10.2174/978160805191511001010120

Transdermal Nanocarriers

Pp: 120-141 (22)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

This chapter aims to show state-of-the-art transd ermal drug-delivery nanocarriers. The advances in this field are very important at present because the skin offe rs many advantages over othe r organs due to its size. Depending on the location, we can deliver drugs very close to the target area. The skin provides protection against microorganisms, temperature, mechanical factors, etc. [1-3]. The development of submicron particles and other nanostructures in the pharmaceutical and cosmetic fields has been employed for the design of formulations for application through the skin [4-7]. The mechanism by which submicron particles traverse the skin is interesting and important as well as size and composition. The nature of drugs that can be applied through the skin offers many possibilities for future therapies. Both lipophilic and hydrophilic compounds can be used for this purpose, depending on the chosen nanocarrier. Finally, rega rding the specific applications of nanocarriers, it is worth mentioning that scientists have used nanocarriers for several applicat ions, including delivery of local and systemic therapies.

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