Frontiers in Medicinal Chemistry

Author(s): Pierre Francotte, Pascal de Tullio, Pierre Fraikin and Bernard Pirotte

DOI: 10.2174/978160805206610603010249

New Trends in the Design of Drugs Against Alzheimer's Disease

Pp: 249-284 (36)

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Abstract

SHS investigation development is considered from the geographical and historical viewpoint. 3 stages are described. Within Stage 1 the work was carried out in the Department of the Institute of Chemical Physics in Chernogolovka where the scientific discovery had been made. At Stage 2 the interest to SHS arose in different cities and towns of the former USSR. Within Stage 3 SHS entered the international scene. Now SHS processes and products are being studied in more than 50 countries.

Abstract

First described by Alois Alzheimer in 1907, Alzheimer's disease (AD) is the most common dementia type, affecting approximately 20 million people worldwide. As the population is getting older, AD is a growing health problem.

AD is currently treated by symptomatic drugs, the acetylcholinesterase inhibitors, based on the cholinergic hypothesis (1976).

During the past decade, advances in neurobiology have conducted to the identification of new targets. Although some of these innovative approaches tend to delay onset of AD, others are still symptomatic.

In this review, we present an overview of the several strategies and new classes of compounds against AD.

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