Abstract

Glioblastoma (GBM) is a highly aggressive and malignant form of brain cancer that is difficult to treat due to the blood-brain barrier (BBB) and drug resistance. Gold nanoparticles (AuNPs) and cold plasma have emerged as promising approaches for GBM therapy due to their unique physical and chemical properties. AuNPs can be engineered to selectively target cancer cells and deliver therapeutic agents, while cold plasma can induce apoptosis and inhibit tumor growth. This book chapter reviews the recent advances in the use of AuNPs and cold plasma for GBM therapy. The chapter discusses the mechanisms of action of AuNPs and cold plasma, as well as the challenges and opportunities for their clinical translation. The chapter also highlights the potential of combining AuNPs and cold plasma for synergistic GBM therapy. Overall, this book chapter provides a comprehensive overview of the current state of the art in the use of AuNPs and cold plasma for GBM therapy.