Modulation of Genotype-Phenotype Associations in Metabolic Syndrome

This chapter provides background information on the genotype-phenotype associations of MetS by highlighting the importance of genetic concepts in modulating MetS. To date, many reports on genetic and epigenetic screening of MetS within a community have been published in the literature. We also mention several reports to perform community-based screening of MetS by identifying genetic and epigenetic variants. Later, these attempts will be discussed in detail in order to explain more about the modulation of MetS from the perspectives of phenotype-genotype associations. The relationship between MetS modulation and the personalized medicine approach is emphasized more by referring to the treatment and management strategies applied in a patient-specific manner. 

Keywords: Genetic predisposition, Modulation, Metabolic syndrome, Management strategies, Personalized medicine.