Reaction to Abnormal Protein Precipitation in the Brain

Pp: 48-62 (15)

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Waste Clearance in the Brain

Reaction to Abnormal Protein Precipitation in the Brain

Author(s): Gaiqing Wang, Haiyun Chen*, Juan Yang, Jing Wang, Bo Yan and Minglei Chen

Pp: 48-62 (15)

DOI: 10.2174/9789815313086124010009

Abstract

The response to abnormal protein deposits in the brain involves a complex interaction among various components of the immune system. Initially, the immune response aims to clear the protein aggregates. However, in neurodegenerative diseases, chronic inflammation and immune dysregulation can occur, leading to additional damage.


Keywords: Autophagy, Inflammatory response, Microglia activation, Phagocytosis.

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