Abstract

A common feature of neurodegenerative diseases is the abnormal accumulation of misfolded proteins in the brain, such as amyloid beta (Aβ), tau, αsynuclein, fused in sarcoma (FUS), and TAR DNA-binding protein 43 (TDP-43), which lead to selective neuronal degeneration and dysfunction. Dysfunction in the removal of these misfolded proteins from the brain, which is thought to be a major cause of neurodegenerative diseases and a major therapeutic target for their cure.